{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:18:55Z","timestamp":1790108335726,"version":"4.0.1"},"reference-count":26,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p>Oral treponemes are members of the spirochete family of bacteria associated with periodontal diseases. In the present study, we demonstrate that intercellular adhesion molecule-1 (ICAM-1) on human gingival epithelial cells (HGEC) contributed to the invasion of Treponema medium , a medium-sized oral Treponema, into those cells. The quantity of T.\u00a0medium in HGEC was found to peak at 2\u00a0h after inoculation and then decreased gradually. Immunofluorescence microscopy findings showed that the bacteria were colocalized with ICAM-1 on HGEC. Furthermore, knockdown of ICAM-1 in HGEC resulted in inhibition of T.\u00a0medium invasion by RNA interference, whereas that of Toll-like receptor 2 did not. These results suggest that ICAM-1 may be required for the invasion of T.\u00a0medium into HGEC, and they indicate that the molecule plays a principal role in the primary stages of the development and progression of chronic periodontitis.<\/jats:p>","DOI":"10.1139\/w07-094","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T17:19:40Z","timestamp":1195233580000},"page":"1232-1238","source":"Crossref","is-referenced-by-count":8,"title":["Possible requirement of intercellular adhesion molecule-1 for invasion of gingival epithelial cells by<i>Treponema medium<\/i>"],"prefix":"10.1139","volume":"53","author":[{"given":"Riyoko","family":"Tamai","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."},{"name":"Department of Oral Anatomy II, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."},{"name":"Department of Oral Anatomy II, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."},{"name":"Department of Oral Anatomy II, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Akisaka","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."},{"name":"Department of Oral Anatomy II, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."},{"name":"Department of Oral Anatomy II, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R300028200"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"atypb3\/ref3","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.12.7387-7395.2001"},{"key":"atypb4\/ref4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3334-3340.2002"},{"key":"atypb5\/ref5","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.717-725.2003"},{"key":"atypb6\/ref6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2000.150101.x"},{"key":"atypb7\/ref7","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1242\/jcs.110.18.2141","volume":"110","author":"Dehio C.","year":"1997","journal-title":"J. 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