{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:10:26Z","timestamp":1791900626960,"version":"4.3.4"},"reference-count":33,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>Bacterial vaginosis (BV) is the most prevalent vaginal infection worldwide and is characterized by depletion of the indigenous lactobacilli. Antimicrobial therapy is often ineffective. We hypothesized that probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 might provide an adjunct to antimicrobial treatment and improve cure rates. Sixty-four Brazilian women diagnosed with BV were randomly assigned to receive a single dose of tinidazole (2\u00a0g) supplemented with either 2 placebo capsules or 2 capsules containing L. rhamnosus GR-1 and L. reuteri RC-14 every morning for the following 4 weeks. At the end of treatment (day 28), the probiotic group had a significantly higher cure rate of BV (87.5%) than the placebo group (50.0%) (p = 0.001). In addition, according to the Gram-stain Nugent score, more women were assessed with \u201cnormal\u201d vaginal microbiota in the probiotic group (75.0% vs. 34.4% in the placebo group; p = 0.011). This study shows that probiotic lactobacilli can provide benefits to women being treated with antibiotics for an infectious condition.<\/jats:p>","DOI":"10.1139\/w08-102","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T10:45:28Z","timestamp":1237286728000},"page":"133-138","source":"Crossref","is-referenced-by-count":135,"title":["Improved cure of bacterial vaginosis with single dose of tinidazole (2\u00a0g),\n                    <i>Lactobacillus rhamnosus<\/i>\n                    GR-1, and\n                    <i>Lactobacillus reuteri<\/i>\n                    RC-14: a randomized, double-blind, placebo-controlled trial"],"prefix":"10.1139","volume":"55","author":[{"given":"Rafael C. R.","family":"Martinez","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, Brazil"},{"name":"Sistema Interno de Sa\u00fade da Universidade de S\u00e3o Paulo, 14055-370 Ribeir\u00e3o Preto, Brazil"},{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-030 Ribeir\u00e3o Preto, Brazil"},{"name":"Canadian Research & Development Centre for Probiotics, F2-116, Lawson Health Research Institute, London, ON N6A\u00a04V2, Canada"},{"name":"Departments of Microbiology and Immunology and Surgery, University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvio A.","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, Brazil"},{"name":"Sistema Interno de Sa\u00fade da Universidade de S\u00e3o Paulo, 14055-370 Ribeir\u00e3o Preto, Brazil"},{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-030 Ribeir\u00e3o Preto, Brazil"},{"name":"Canadian Research & Development Centre for Probiotics, F2-116, Lawson Health Research Institute, London, ON N6A\u00a04V2, Canada"},{"name":"Departments of Microbiology and Immunology and Surgery, University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela C.","family":"Patta","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, Brazil"},{"name":"Sistema Interno de Sa\u00fade da Universidade de S\u00e3o Paulo, 14055-370 Ribeir\u00e3o Preto, Brazil"},{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-030 Ribeir\u00e3o Preto, Brazil"},{"name":"Canadian Research & Development Centre for Probiotics, F2-116, Lawson Health Research Institute, London, ON N6A\u00a04V2, Canada"},{"name":"Departments of Microbiology and Immunology and Surgery, University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana M.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, Brazil"},{"name":"Sistema Interno de Sa\u00fade da Universidade de S\u00e3o Paulo, 14055-370 Ribeir\u00e3o Preto, Brazil"},{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-030 Ribeir\u00e3o Preto, Brazil"},{"name":"Canadian Research & Development Centre for Probiotics, F2-116, Lawson Health Research Institute, London, ON N6A\u00a04V2, Canada"},{"name":"Departments of Microbiology and Immunology and Surgery, University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna C.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-903 Ribeir\u00e3o Preto, Brazil"},{"name":"Sistema Interno de Sa\u00fade da Universidade de S\u00e3o Paulo, 14055-370 Ribeir\u00e3o Preto, Brazil"},{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 14040-030 Ribeir\u00e3o Preto, Brazil"},{"name":"Canadian Research & Development Centre for Probiotics, F2-116, Lawson Health Research Institute, London, ON N6A\u00a04V2, Canada"},{"name":"Departments of Microbiology and Immunology and Surgery, University of Western Ontario, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine C. 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