{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:02:16Z","timestamp":1790326936634,"version":"4.1.0"},"reference-count":31,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Microbiol."],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>The gene expression of human brain microvascular endothelial cells (HBMEC) in response to 4\u00a0h of infection by Listeria monocytogenes was analyzed. Four hours after infection, the expression of 456 genes of HBMEC had changed (p\u00a0&lt; 0.05). We noted that many active genes were involved in the formyl-methionyl-leucyl-phenylalanine pathway in infected HBMEC. In the upregulated genes, mRNA levels of interleukin-8 and\u00a0interleukin-15 in infected cells increased according to microarray and real-time reverse transcription \u2013 PCR analyses. Since both cytokines are regarded as potent chemotactic factors, the results suggest that HBMEC are capable of recruiting cells of innate and adaptive immune responses during early L. monocytogenes infection.<\/jats:p>","DOI":"10.1139\/w11-018","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T16:40:51Z","timestamp":1305045651000},"page":"441-446","source":"Crossref","is-referenced-by-count":5,"title":["Early gene response of human brain microvascular endothelial cells to<i>Listeria monocytogenes<\/i>infection"],"prefix":"10.1139","volume":"57","author":[{"given":"Chinling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsi","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University Calumet, Hammond, IN 46323-2094, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijin","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, South Dakota State University, Brookings, SD 57007, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesya M.","family":"Pinchuk","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"issue":"6","key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/jlb.61.6.729","volume":"61","author":"Allavena P.","year":"1997","journal-title":"J. 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