{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:23:56Z","timestamp":1757589836063},"reference-count":28,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>Selected parameters of cardiovascular function were evaluated in vitamin A-deficient rats at 70 days of age. Resting heart rate was increased by an average of 100 bpm (21.4 \u00b1 2.7%), whereas resting systolic blood pressure was normal in vitamin A-deficient animals. The maximal contractile force developed per milligram weight of tissue by aortic rings excised from vitamin A-deficient animals was reduced in response to high potassium (\u009625.0 \u00b1 8.7%) and phorbol 12,13-dibutyrate (\u009636.8 \u00b1 8.4%) but was only slightly reduced in response to norepinephrine (\u009617.8 \u00b1 11.1%). Intimal rubbing to remove the endothelium had no effect on the loss in contractile responsiveness, and the relaxant response to acetylcholine was similar between control and vitamin A-deficient tissue groups. This suggests that the decrease in contractility of vascular smooth muscle from the vitamin A-deficient rats did not involve altered release of endothelium-derived vasoactive factors. Western blot analysis suggested a reduction in the protein levels of several differentiation markers including \u03b1-actin (\u009622%), calponin (\u009637%), desmin (\u009637%), and vinculin (\u009640%), whereas the level of PKC\u03b1 was unchanged from control values. Our findings indicate a significant decrease in contractile responsiveness of aortic smooth muscle of the vitamin A-deficient rat that may be associated with a down regulation in the expression of contractile-related proteins.Key words: vitamin A, retinoids, in vivo, cardiovascular, contractility, blood pressure.<\/jats:p>","DOI":"10.1139\/y01-093","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:57:36Z","timestamp":1027767456000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Effect of vitamin A deficiency on cardiovascular function in the rat"],"prefix":"10.1139","volume":"80","author":[{"given":"G L","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Fultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Arif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B S","family":"Chertow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0007114500001318","volume":"84","author":"Antipatis C.","year":"2000","journal-title":"Brit. 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