{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:48:25Z","timestamp":1761742105740},"reference-count":42,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p> A frequent side effect in the long-term treatment of schizophrenia with the dopamine D<jats:sub>2<\/jats:sub> antagonist haloperidol (HAL) is the appearance of tardive dyskinesia or, in animals, of repetitive involuntary vacuous chewing movements (VCMs). In rats, chronic HAL-induced or D<jats:sub>1<\/jats:sub> receptor-stimulated VCMs are suppressed by D<jats:sub>1<\/jats:sub> antagonists, suggesting that this behavioral supersensitivity is mediated by D<jats:sub>1<\/jats:sub> receptors. The goal of this study was to investigate in vivo the possible relationship between D<jats:sub>1<\/jats:sub> receptor binding and D<jats:sub>1<\/jats:sub>-mediated behavioral supersensitivity, after sub-chronic HAL treatments. D<jats:sub>1<\/jats:sub> agonist R-SKF 82957 and antagonist SCH 23390, both labeled with carbon-11, were used to assess in vivo D<jats:sub>1<\/jats:sub> receptor binding. Rats were treated with HAL (1.5 mg\/kg, i.p.) or vehicle for 21 days, followed by a 4 day washout period. No significant difference was found in the regional brain binding of either radioligand. D<jats:sub>1<\/jats:sub> receptor-mediated behaviors including VCMs, grooming, and rearing were measured in control or HAL-treated rats. VCMs were significantly increased in HAL-treated rats, suggesting D<jats:sub>1<\/jats:sub> receptor stimulation and possibly receptor supersensitivity. This study failed to link the purported D<jats:sub>1<\/jats:sub> receptor-mediated behaviors with in vivo receptor binding measures of R-[<jats:sup>11<\/jats:sup>C]SKF 82957 or [<jats:sup>11<\/jats:sup>C]SCH 23390 in rat brain regions.Key words: typical neuroleptics, vacuous chewing movements, behavioral D<jats:sub>1<\/jats:sub> supersensitivity, tardive dyskinesia, positron emission tomography. <\/jats:p>","DOI":"10.1139\/y02-002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:57:36Z","timestamp":1027753056000},"page":"36-41","source":"Crossref","is-referenced-by-count":4,"title":["No change in dopamine D<sub>1<\/sub> receptor in vivo binding in rats after sub-chronic haloperidol treatment"],"prefix":"10.1139","volume":"80","author":[{"given":"Vito","family":"Sanci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Houle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean N","family":"DaSilva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s007020050142","volume":"106","author":"Ase A.R.","year":"1999","journal-title":"J. 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