{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:38:55Z","timestamp":1791301135073,"version":"4.1.0"},"reference-count":16,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p> The purpose of this study was to investigate the effects of [Nphe<jats:sup>1<\/jats:sup>]nociceptin(1\u009613)-NH<jats:sub>2<\/jats:sub> on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) of the anesthetized rat. The results showed that i.c.v. or i.v. [Nphe<jats:sup>1<\/jats:sup>]nociceptin(1\u009613)-NH<jats:sub>2<\/jats:sub> (1.5\u009612 nmol\/kg and 5-120 nmol\/kg, respectively) could antagonize the depressor effects of i.c.v. or i.v. nociceptin (3 and 30 nmol\/kg, respectively) on MAP and HR. Furthermore, [Nphe<jats:sup>1<\/jats:sup>]nociceptin(1\u009613)-NH<jats:sub>2<\/jats:sub> (5\u0096120 nmol\/kg) could reverse nociceptin (30 nmol\/kg)-induced decrease of HVBR. However, [Nphe<jats:sup>1<\/jats:sup>]nociceptin(1\u009613)-NH<jats:sub>2<\/jats:sub> had no significant effects on similar effects induced by morphine. Our results suggest that [Nphe<jats:sup>1<\/jats:sup>]nociceptin(1\u009613)-NH<jats:sub>2<\/jats:sub> acts as a selective antagonist of the nociceptin receptor in the cardiovascular system of the rat.Key words: nociceptin, [Nphe<jats:sup>1<\/jats:sup>]nociceptin(1\u009613)-NH<jats:sub>2<\/jats:sub>, morphine, mean arterial pressure, heart rate, hindquarters vascular bed resistance. <\/jats:p>","DOI":"10.1139\/y02-003","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:57:36Z","timestamp":1027753056000},"page":"31-35","source":"Crossref","is-referenced-by-count":13,"title":["[Nphe<sup>1<\/sup>]nociceptin(1\u009613)-NH<sub>2<\/sub> antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat"],"prefix":"10.1139","volume":"80","author":[{"given":"Y","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z Z","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L X","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y M","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","first-page":"428","volume":"294","author":"Berger H.","year":"2000","journal-title":"J. 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