{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:41:55Z","timestamp":1771825315466,"version":"3.50.1"},"reference-count":67,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p> The effects of \u03b2-cyclodextrin (\u03b2CD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied. Violacein\u0096\u03b2CD inclusion complexes were prepared in 1:1 and 1:2 molar ratios and analysed by differential scanning calorimetry and powder X-ray diffractometry. Violacein previously administered orally at 10 mg\/kg significantly reduced indomethacin-induced gastric lesions, as well as 100 mg\/kg of cimetidine (positive control). However, \u03b2CD complexation in both molar ratios significantly potentiated the protective action of violacein. In the HCl\u0096ethanol-induced gastric ulcer model, violacein and the 1:2 inclusion complex (10 mg\/kg, p.o.) inhibited gastric damage by almost 85%, whereas a 63% reduction was observed for the positive control, lansoprazole, at 30 mg\/kg. In contrast, treatment with the 1:1 inclusion complex resulted in almost total disappearance of the antiulcer activity in this model. No significant changes in stress-induced gastric injury were found. In addition, the 1:2 inclusion complex improved the antilipoperoxidant activity of violacein in rat liver cells exposed to t-butyl hydroperoxide, whereas the 1:1 complex was less active than violacein. In summary, the 1:2 \u03b2CD inclusion complex has gastroprotective properties similar to or higher than that of violacein. An increase in mucosal defensive mechanisms and protection against peroxidative damage might be involved.Key words: violacein, \u03b2-cyclodextrin, gastric ulcer, lipid peroxidation, hepatocyte. <\/jats:p>","DOI":"10.1139\/y03-033","type":"journal-article","created":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T16:23:32Z","timestamp":1055780612000},"page":"387-396","source":"Crossref","is-referenced-by-count":40,"title":["Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with \u03b2-cyclodextrin"],"prefix":"10.1139","volume":"81","author":[{"given":"Nelson","family":"Dur\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle Z","family":"Justo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia S","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e2ngela B.M","family":"De Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba R.M","family":"Souza Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana B.A","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Haun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-5173(98)00163-X","volume":"171","author":"Ahmed M.O.","year":"1998","journal-title":"Int. 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