{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:17:16Z","timestamp":1770473836408,"version":"3.49.0"},"reference-count":27,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:p>We investigated the changes in insulin resistance and adipose tissue expression of the adipokines resistin, adiponectin, and leptin and the transcription factors peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3) and retinoid X receptor-\u03b1 (RXR-\u03b1) during 48 h of food deprivation. Insulin sensitivity (S<jats:sub>I<\/jats:sub>) declined, whereas glucose effectiveness (S<jats:sub>G<\/jats:sub>) increased. Plasma adiponectin levels declined in the first 8 h and remained constant thereafter. There was no correlation between either S<jats:sub>I<\/jats:sub>or S<jats:sub>G<\/jats:sub>and adiponectin protein or mRNA levels. PPAR-\u03b3 mRNA abundance remained constant, whereas leptin and resistin mRNAs and plasma leptin declined and RXR-\u03b1 mRNA abundance increased in both white and brown fat. Leptin mRNA abundance was closely correlated with S<jats:sub>I<\/jats:sub>(R<jats:sup>2<\/jats:sup>= 0.91 and 0.87 for white and brown fat, respectively). Resistin mRNA abundance correlated inversely with S<jats:sub>G<\/jats:sub>(R<jats:sup>2<\/jats:sup>= 0.99 and 0.84 for white and brown fat, respectively). These data indicate that changes in the expression of leptin are more closely correlated with the insulin resistance of fasting than with changes in other adipokines or RXR-\u03b1 and PPAR-\u03b3 expression.Key words: insulin resistance, fasting, adipokines, resistin, leptin, adiponectin.<\/jats:p>","DOI":"10.1139\/y03-103","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T07:16:47Z","timestamp":1067325407000},"page":"979-985","source":"Crossref","is-referenced-by-count":15,"title":["Changes in adipokine expression during food deprivation in the mouse and the relationship to fasting-induced insulin resistance"],"prefix":"10.1139","volume":"81","author":[{"given":"Yaoting","family":"Gui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef V","family":"Silha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam J","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/oby.2003.75","volume":"11","author":"Chu N.F.","year":"2003","journal-title":"Obes. 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