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The focus of this paper concerns the potassium (K<jats:sup>+<\/jats:sup>) channels that provide a negative feedback control of the myogenic depolarization of vascular smooth muscle cells that is provoked by elevations in intraluminal pressure, and specifically, the contribution of delayed rectifier (K<jats:sub>DR<\/jats:sub>) channels. Our knowledge of the important role played by K<jats:sub>DR<\/jats:sub>channels, as well as their molecular identity and acute modulation via changes in gating, has increased dramatically in recent years. Several lines of evidence point to a crucial contribution by heteromultimeric K<jats:sub>V<\/jats:sub>1 subunit-containing K<jats:sub>DR<\/jats:sub>channels in the control of arterial diameter and myogenic reactivity, but other members of the K<jats:sub>V<\/jats:sub>superfamily are also expressed by vascular myocytes, and less is known concerning their specific functions. The effect of pharmacological modulation of K<jats:sub>DR<\/jats:sub>channels is discussed, with particular reference to the actions of anorexinogens on K<jats:sub>V<\/jats:sub>1- and K<jats:sub>V<\/jats:sub>2-containing K<jats:sub>DR<\/jats:sub>channels. Finally, the need for a greater understanding of the mechanisms that control K<jats:sub>DR<\/jats:sub>channel gene expression is stressed in light of evidence indicating that there is a reduced expression of K<jats:sub>DR<\/jats:sub>channels in diseases associated with abnormal myogenic reactivity and vascular remodelling.Key words: resistance arteries, myogenic response, potassium channels, delayed rectifier K<jats:sup>+<\/jats:sup>current, K<jats:sub>V<\/jats:sub>channels, K<jats:sub>V<\/jats:sub>1, K<jats:sub>V<\/jats:sub>2.<\/jats:p>","DOI":"10.1139\/y05-082","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T20:35:46Z","timestamp":1133901346000},"page":"755-765","source":"Crossref","is-referenced-by-count":21,"title":["Myogenic regulation of arterial diameter: role of potassium channels with a focus on delayed rectifier potassium current"],"prefix":"10.1139","volume":"83","author":[{"given":"William C","family":"Cole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim T","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Cl\u00e9ment-Chomienne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_1\/p_1_1","first-page":"H2061","volume":"287","author":"Ahmed A.","year":"2004","journal-title":"Am. 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