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The critical role of the ubiquitin\u2013proteasome pathway in viral pathogenesis has become increasingly apparent. Many viruses have been reported to evolve different strategies to utilize the ubiquitin\u2013proteasome pathway for their own benefits. Here, we review the general background and function of the ubiquitin\u2013proteasome pathway, summarize our current understanding of how viruses use this pathway to target cellular proteins, and finally, discuss the roles of this pathway in enteroviral infection, and the potential therapeutic application of proteasome inhibition in myocarditis.<\/jats:p>","DOI":"10.1139\/y05-144","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T17:25:00Z","timestamp":1144430700000},"page":"5-14","source":"Crossref","is-referenced-by-count":140,"title":["The ubiquitin\u2013proteasome pathway in viral infectionsThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum."],"prefix":"10.1139","volume":"84","author":[{"given":"Guang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia \u2013 St. Paul's Hospital, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia \u2013 St. Paul's Hospital, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(03)02647-3"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00508a009"},{"key":"atypb3\/ref3","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.12.6323-6331.2002"},{"key":"atypb4\/ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor824"},{"key":"atypb5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(03)00141-5"},{"key":"atypb6\/ref6","doi-asserted-by":"crossref","first-page":"H2612","DOI":"10.1152\/ajpheart.2001.281.6.H2612","volume":"281","author":"Bao J.","year":"2001","journal-title":"Am. 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