{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:03:21Z","timestamp":1761743001905,"version":"3.33.0"},"reference-count":33,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>Components of whole blood and plasma are highly altered during the presentation of nephrotic syndrome. The present study was aimed to explore the influence of nephrotic syndrome on the pharmacokinetics of cyclosporine (CsA) (10\u00a0mg\/kg) administered i.v. to control or puromycin-induced nephrotic rats (P-NS). We found an increase in CsA bioavailability in the nephrotic group compared with controls. The area under the curve of blood CsA versus time (AUC<jats:sub>iv<\/jats:sub>) increased from 27.7\u00a0\u00b1 5.3\u00a0to 60.6\u00a0\u00b1 13.8 \u03bcg\u00b7h\u00b7mL<jats:sup>\u20131<\/jats:sup>in control and P-NS rats, respectively. The AUC<jats:sub>iv<\/jats:sub>augmentation was positively correlated with cholesterol levels. On the other hand, the total body clearance was significantly lower (0.38\u00a0\u00b1 0.06 vs. 0.17\u00a0\u00b1 0.03 L\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup>\u00b7h<jats:sup>\u20131<\/jats:sup>) and the volume of distribution at steady state (3.70\u00a0\u00b1 0.52 vs. 2.85\u00a0\u00b1 0.32 L\/kg) was significantly smaller in nephrotic rats as compared with control. These pharmacokinetic changes lead to a longer terminal half-life of CsA in P-NS rats (11.8\u00a0\u00b1 1.6 vs. 6.9\u00a0\u00b1 0.91\u00a0h). We conclude that the physiopathologic changes induced by the nephrotic syndrome in P-NS animals result in a significant increase in CsA blood exposure by both the decrease in drug distribution and the reduction in elimination rate of CsA.<\/jats:p>","DOI":"10.1139\/y07-025","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T18:21:20Z","timestamp":1184869280000},"page":"502-506","source":"Crossref","is-referenced-by-count":2,"title":["Increased cyclosporine bioavailability induced by experimental nephrotic syndrome in rats"],"prefix":"10.1139","volume":"85","author":[{"given":"Mara","family":"Medeiros","sequence":"first","affiliation":[{"name":"Departamento de Nefrologia, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Dr. Marquez 162, Col. Doctores, Mexico, DF 06720, Mexico."},{"name":"Facultad de Ciencias Qu\u00edmicas, UASLP, Dr Nava No.6. Zona Universitaria, San Luis, San Luis Potosi 78200, Mexico."},{"name":"Facultad de Qu\u00edmica, Circuito Escolar, Ciudad Universitaria, UNAM, Mexico, DF 04510, Mexico."},{"name":"Secci\u00f3n Externa de Farmacolog\u00eda, CINVESTAV-IPN, Av. Instituto Polit\u00e9cnico Nacional 2508. Colonia San Pedro Zacatenco, Mexico, DF 07360, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"P\u00e9rez-Urizar","sequence":"additional","affiliation":[{"name":"Departamento de Nefrologia, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Dr. Marquez 162, Col. Doctores, Mexico, DF 06720, Mexico."},{"name":"Facultad de Ciencias Qu\u00edmicas, UASLP, Dr Nava No.6. Zona Universitaria, San Luis, San Luis Potosi 78200, Mexico."},{"name":"Facultad de Qu\u00edmica, Circuito Escolar, Ciudad Universitaria, UNAM, Mexico, DF 04510, Mexico."},{"name":"Secci\u00f3n Externa de Farmacolog\u00eda, CINVESTAV-IPN, Av. Instituto Polit\u00e9cnico Nacional 2508. Colonia San Pedro Zacatenco, Mexico, DF 07360, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Pedraza-Chaverri","sequence":"additional","affiliation":[{"name":"Departamento de Nefrologia, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Dr. Marquez 162, Col. Doctores, Mexico, DF 06720, Mexico."},{"name":"Facultad de Ciencias Qu\u00edmicas, UASLP, Dr Nava No.6. Zona Universitaria, San Luis, San Luis Potosi 78200, Mexico."},{"name":"Facultad de Qu\u00edmica, Circuito Escolar, Ciudad Universitaria, UNAM, Mexico, DF 04510, Mexico."},{"name":"Secci\u00f3n Externa de Farmacolog\u00eda, CINVESTAV-IPN, Av. Instituto Polit\u00e9cnico Nacional 2508. Colonia San Pedro Zacatenco, Mexico, DF 07360, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Mu\u00f1oz-Arizpe","sequence":"additional","affiliation":[{"name":"Departamento de Nefrologia, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Dr. Marquez 162, Col. Doctores, Mexico, DF 06720, Mexico."},{"name":"Facultad de Ciencias Qu\u00edmicas, UASLP, Dr Nava No.6. Zona Universitaria, San Luis, San Luis Potosi 78200, Mexico."},{"name":"Facultad de Qu\u00edmica, Circuito Escolar, Ciudad Universitaria, UNAM, Mexico, DF 04510, Mexico."},{"name":"Secci\u00f3n Externa de Farmacolog\u00eda, CINVESTAV-IPN, Av. Instituto Polit\u00e9cnico Nacional 2508. Colonia San Pedro Zacatenco, Mexico, DF 07360, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Casta\u00f1eda-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Nefrologia, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, Dr. Marquez 162, Col. Doctores, Mexico, DF 06720, Mexico."},{"name":"Facultad de Ciencias Qu\u00edmicas, UASLP, Dr Nava No.6. Zona Universitaria, San Luis, San Luis Potosi 78200, Mexico."},{"name":"Facultad de Qu\u00edmica, Circuito Escolar, Ciudad Universitaria, UNAM, Mexico, DF 04510, Mexico."},{"name":"Secci\u00f3n Externa de Farmacolog\u00eda, CINVESTAV-IPN, Av. Instituto Polit\u00e9cnico Nacional 2508. Colonia San Pedro Zacatenco, Mexico, DF 07360, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","first-page":"S48","volume":"35","author":"Collaborative Study Group of Sandimmun in Nephrotic Syndrome","year":"1991","journal-title":"Clin. Nephrol."},{"key":"atypb2\/ref33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/neu.2006.23.75","volume":"23","author":"Cruz-Antonio L.","year":"2006","journal-title":"J. Neurotrauma."},{"key":"atypb3\/ref2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000189558","volume":"75","author":"Desassis J.F.","year":"1997","journal-title":"Nephron"},{"key":"atypb4\/ref3","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/ndt\/gfh803","volume":"20","author":"Filler G.","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"atypb5\/ref4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0005-2760(82)90149-7","volume":"710","author":"Gherardi E.","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb6\/ref5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.2042-7158.1992.tb05511.x","volume":"44","author":"Granados Soto V.","year":"1992","journal-title":"J. Pharm. Pharmacol."},{"key":"atypb7\/ref6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1681\/ASN.V74543","volume":"7","author":"Gregory M.J.","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"atypb8\/ref7","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1172\/JCI108035","volume":"55","author":"Gugler R.","year":"1975","journal-title":"J. Clin. Invest."},{"key":"atypb9\/ref8","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0040802"},{"key":"atypb10\/ref9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1681\/ASN.V32254","volume":"3","author":"Ingulli E.","year":"1992","journal-title":"J. Am. Soc. Nephrol."},{"key":"atypb11\/ref10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0022-3565(24)37815-2","volume":"287","author":"Kawai R.","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"atypb12\/ref11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000168649","volume":"13","author":"Kaysen G.A.","year":"1993","journal-title":"Am. J. Nephrol."},{"key":"atypb13\/ref12","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711660313"},{"key":"atypb14\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00382-8"},{"key":"atypb15\/ref14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.2042-7158.1982.tb06206.x","volume":"34","author":"Lemaire M.","year":"1982","journal-title":"J. Pharm. Pharmacol."},{"key":"atypb16\/ref15","unstructured":"Ley General de Salud. 1995. T\u00edtulo S\u00e9ptimo. De la investigaci\u00f3n que incluya la utilizaci\u00f3n de animales de experimentaci\u00f3n, in Ley General de salud. Editorial Porr\u00faa, M\u00e9xico D.F. pp.\u00a0430\u2013431."},{"key":"atypb17\/ref16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1681\/ASN.V7156","volume":"7","author":"Lieberman K.V.","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"atypb18\/ref17","doi-asserted-by":"publisher","DOI":"10.1007\/S00467-006-0300-6"},{"key":"atypb19\/ref18","first-page":"17","volume":"10","author":"Moulin B.","year":"1989","journal-title":"Nephrologie"},{"key":"atypb20\/ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050537"},{"key":"atypb21\/ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1844-6"},{"key":"atypb22\/ref21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/08860229609052788","volume":"18","author":"Pedraza-Chaverri J.","year":"1996","journal-title":"Ren. Fail."},{"key":"atypb23\/ref22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/cpt1978242199","volume":"24","author":"Rane A.","year":"1978","journal-title":"Clin. Pharmacol. Ther."},{"key":"atypb24\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(98)00004-6"},{"key":"atypb25\/ref24","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711480410"},{"key":"atypb26\/ref25","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772592"},{"key":"atypb27\/ref26","first-page":"377","volume":"65","author":"Tanabe T.","year":"1990","journal-title":"Hokkaido Igaku Zasshi"},{"key":"atypb28\/ref27","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020978509566"},{"key":"atypb29\/ref28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2165\/00003088-199528050-00005","volume":"28","author":"Vrhovac B.","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"atypb30\/ref29","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1159\/000187523","volume":"65","author":"Wang J.S.","year":"1993","journal-title":"Nephron"},{"key":"atypb31\/ref30","first-page":"S70","volume":"14","author":"Wheeler D.C.","year":"2001","journal-title":"J. Nephrol."},{"key":"atypb32\/ref31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cpt1975184377","volume":"18","author":"Wilkinson G.R.","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"key":"atypb33\/ref32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1440-1827.1995.tb03487.x","volume":"45","author":"Yamazaki T.","year":"1995","journal-title":"Pathol. Int."}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/Y07-025","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/Y07-025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T18:14:45Z","timestamp":1737310485000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/Y07-025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1139\/Y07-025"],"URL":"https:\/\/doi.org\/10.1139\/y07-025","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"type":"print","value":"0008-4212"},{"type":"electronic","value":"1205-7541"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}