{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:03:38Z","timestamp":1755925418611},"reference-count":47,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p> Natural health products (NHPs) or complementary and alternative medicine (CAM) are commonly used to prevent disorders or support the usual treatments of many diseases. XP-828L, a whey protein extract, has demonstrated potential benefits for the treatment of mild to moderate psoriasis. The aim of this study was to analyze further clinical data that demonstrated the clinical benefits and safety of the XP-828L in patients with psoriasis and the potential mechanism of action of this product in vitro. Oral administration (2.5\u00a0g, twice a day, over 112\u00a0days) of XP-828L in 42 human subjects with mild to moderate psoriasis improved their PGA scores (physician\u2019s global assessment). Moreover, no significant changes in haematology or hepatic and renal parameters were observed throughout the study period, indicating the safety of the product. In vitro experiments showed that XP-828L decreased the proliferation of concanavalin A (ConA)-stimulated murine splenocytes and their production of interleukin (IL)-2 and interferon (IFN)-\u03b3. Although the in vivo mechanism of action of XP-828L remains unknown, XP-828L represents an NHP to be used as an alternative or concomitant treatment for mild to moderate psoriasis and potentially for other immune-mediated diseases. <\/jats:p>","DOI":"10.1139\/y07-084","type":"journal-article","created":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T11:16:55Z","timestamp":1197026215000},"page":"943-951","source":"Crossref","is-referenced-by-count":10,"title":["XP-828L (Dermylex), a new whey protein extract with potential benefit for mild to moderate psoriasisThis article is one of a selection of papers published in this special issue (part 1 of 2) on the Safety and Efficacy of Natural Health Products."],"prefix":"10.1139","volume":"85","author":[{"given":"R\u00e9jean","family":"Drouin","sequence":"first","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ric","family":"Lamiot","sequence":"additional","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Cantin","sequence":"additional","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie F.","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Pouliot","sequence":"additional","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice E.","family":"Poubelle","sequence":"additional","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Juneau","sequence":"additional","affiliation":[{"name":"Advitech Inc., 1165, boulevard Lebourgneuf, Suite 140, Qu\u00e9bec, QC G2K\u00a02C9, Canada."},{"name":"STELA Dairy Research Centre, Nutraceuticals and Functional Foods Institute (INAF), Universit\u00e9 Laval, Qu\u00e9bec, QC G1K\u00a07P4, Canada."},{"name":"Centre de Recherche en Rhumatologie et Immunologie (CRCHUL), Universit\u00e9 Laval, Qu\u00e9bec, QC G1V\u00a04G2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00749.x"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000073094"},{"key":"atypb3\/ref3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2796.1989.tb01462.x","volume":"731","author":"Bjorneboe A.","year":"1989","journal-title":"J. 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