{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:13:08Z","timestamp":1697386388049},"reference-count":29,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p> The aim of this study was to determine the mechanism of transport of <jats:sup>14<\/jats:sup>C-thiamin in the hearts of healthy (nonalcoholic) and chronically alcoholic guinea pigs. We used the single-pass, paired-tracer dilution method on isolated and retrogradely perfused guinea pig hearts. The maximal cellular uptake (U<jats:sub>max<\/jats:sub>) and total cellular uptake (U<jats:sub>tot<\/jats:sub>) of <jats:sup>14<\/jats:sup>C-thiamin were determined under control conditions and under influence of possible modifiers. We tested how the presence of unlabeled thiamin, metabolic inhibitors, or absence of sodium ions influence the transport of <jats:sup>14<\/jats:sup>C-thiamin. The results of our experiments show that the transport of <jats:sup>14<\/jats:sup>C-thiamin is specific and energy-dependent and that its properties are significantly changed under the influence of chronic alcoholism. The latter effect occurs by increase in both U<jats:sub>max<\/jats:sub> and U<jats:sub>tot<\/jats:sub>, as a manifestation of a compensatory mechanism in thiamin deficiency. <\/jats:p>","DOI":"10.1139\/y08-013","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T08:37:13Z","timestamp":1208335033000},"page":"160-165","source":"Crossref","is-referenced-by-count":2,"title":["Properties of thiamin transport in isolated perfused hearts of chronically alcoholic guinea pigsThis article is one of a selection of papers published in the special issue Bridging the Gap: Where Progress in Cardiovascular and Neurophysiologic Research Meet."],"prefix":"10.1139","volume":"86","author":[{"given":"Milos M.","family":"Petrovic","sequence":"first","affiliation":[{"name":"Institute of Physiology, School of Medicine, Visegradska 26\/II, Belgrade 11000, Serbia."},{"name":"University of Kragujevac, Faculty of Medicine, Svetozara Markovica 69, Kragujevac 34000, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Scepanovic","sequence":"additional","affiliation":[{"name":"Institute of Physiology, School of Medicine, Visegradska 26\/II, Belgrade 11000, Serbia."},{"name":"University of Kragujevac, Faculty of Medicine, Svetozara Markovica 69, Kragujevac 34000, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gvozden","family":"Rosic","sequence":"additional","affiliation":[{"name":"Institute of Physiology, School of Medicine, Visegradska 26\/II, Belgrade 11000, Serbia."},{"name":"University of Kragujevac, Faculty of Medicine, Svetozara Markovica 69, Kragujevac 34000, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusan M.","family":"Mitrovic","sequence":"additional","affiliation":[{"name":"Institute of Physiology, School of Medicine, Visegradska 26\/II, Belgrade 11000, Serbia."},{"name":"University of Kragujevac, Faculty of Medicine, Svetozara Markovica 69, Kragujevac 34000, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0232-1513(88)80073-2","volume":"33","author":"Baruah J.K.","year":"1988","journal-title":"Exp. 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