{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:20:22Z","timestamp":1773451222437,"version":"3.50.1"},"reference-count":36,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>The penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We hypothesized that cavernosal responses to ET-1 are enhanced in deoxycorticosterone acetate (DOCA)-salt mice and that blockade of ET<jats:sub>A<\/jats:sub>receptors prevents abnormal responses of the corpus cavernosum in DOCA-salt hypertension. Male C57BL\/6 mice were unilaterally nephrectomized and treated for 5\u00a0weeks with both DOCA and water containing 1% NaCl and 0.2% KCl. Control mice were uninephrectomized and received tap water with no added salt. Animals received either the ET<jats:sub>A<\/jats:sub>antagonist atrasentan (5\u00a0mg\u00b7day<jats:sup>\u22121<\/jats:sup>\u00b7kg<jats:sup>\u22121<\/jats:sup>body weight) or vehicle. DOCA-salt mice displayed increased systolic blood pressure (SBP), and treatment with atrasentan decreased SBP in DOCA-salt mice. Contractile responses in cavernosal strips from DOCA-salt mice were enhanced by ET-1, phenylephrine, and electrical field stimulation (EFS) of adrenergic nerves, whereas relaxations were not altered by IRL-1620 (an ET<jats:sub>B<\/jats:sub>agonist), acetylcholine, sodium nitroprusside, and EFS of nonadrenergic noncholinergic nerves. PD59089 (an ERK1\/2 inhibitor), but not Y-27632 (a Rho-kinase inhibitor), abolished enhanced contractions to ET-1 in cavernosum from DOCA-salt mice. Treatment of DOCA-salt mice with atrasentan did not normalize cavernosal responses. In summary, DOCA-salt treatment in mice enhances cavernosal reactivity to contractile, but not to relaxant, stimuli, via ET-1\/ET<jats:sub>A<\/jats:sub>receptor-independent mechanisms.<\/jats:p>","DOI":"10.1139\/y08-031","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T19:06:48Z","timestamp":1212174408000},"page":"320-328","source":"Crossref","is-referenced-by-count":28,"title":["DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosumThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin."],"prefix":"10.1139","volume":"86","author":[{"given":"Fernando S.","family":"Carneiro","sequence":"first","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda R.C.","family":"Giachini","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor V.","family":"Lima","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zidonia N.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00eania P.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adviye","family":"Ergul","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romulo","family":"Leite","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita C.","family":"Tostes","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Department of Physiology, 1120 Fifteenth Street, CA-3141, Augusta, GA 30912-3000, USA."},{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil."},{"name":"Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG-Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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