{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:16:15Z","timestamp":1782857775578,"version":"3.54.5"},"reference-count":35,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>Glucocorticoids may improve lung function in newborns with meconium aspiration syndrome (MAS), but information on the acute side effects of glucocorticoids in infants is limited. In this study using a rabbit model of MAS, we addressed the hypothesis that systemic administration of dexamethasone causes acute cardiovascular changes. Adult rabbits were treated with 2 intravenous doses of dexamethasone (0.5\u00a0mg\/kg each) or saline at 0.5\u00a0h and 2.5\u00a0h after intratracheal instillation of human meconium or saline. Animals were oxygen-ventilated for 5\u00a0h after the first dose of treatment. Blood pressure, heart rate, and short-term heart rate variability (HRV) were analyzed during treatment, for 5 min immediately after each dose, and for the 5\u00a0h of the experiment. In the meconium-instilled animals, dexamethasone increased blood pressure, decreased heart rate, increased HRV parameters, and caused cardiac arrhythmia during and immediately after administration. In the saline-instilled animals, the effect of dexamethasone was inconsistent. In these animals, the acute effects of dexamethasone on blood pressure and cardiac rhythm were reversed after 30\u00a0min, whereas heart rate continued to decrease and HRV parameters continued to increase for 5\u00a0h after the first dose of dexamethasone. These effects were more pronounced in meconium-instilled animals. If systemic glucocorticoids are used in the treatment of MAS, cardiovascular side effects of glucocorticoids should be considered.<\/jats:p>","DOI":"10.1139\/y08-086","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T18:37:59Z","timestamp":1226687879000},"page":"804-814","source":"Crossref","is-referenced-by-count":12,"title":["Rapid cardiovascular effects of dexamethasone in rabbits with meconium-induced acute lung injury"],"prefix":"10.1139","volume":"86","author":[{"given":"Daniela","family":"Mokra","sequence":"first","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Tonhajzerova","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Mokry","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Drgova","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Petraskova","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Calkovska","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Javorka","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."},{"name":"Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2379"},{"key":"atypb2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(01)00171-4"},{"key":"atypb3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70025-0"},{"key":"atypb4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s004310000678"},{"key":"atypb5\/ref5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0031-6997(24)01468-6","volume":"52","author":"Falkenstein E.","year":"2000","journal-title":"Pharmacol. 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