{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:20:24Z","timestamp":1772004024962,"version":"3.50.1"},"reference-count":40,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p> Quercetin has been shown to possess beneficial pharmacological properties in treatment of heart disease, but lack of stability and bioavailability limits its clinical use. In this study, we investigated for the first time the effect of a methylated form of quercetin, 3,3\u2032,4\u2032,5,7-pentamethylquercetin (PMQ), on myocardial protection in rats. Angiotensin\u00a0II was delivered to Sprague\u2013Dawley rats subcutaneously, while PMQ (5\u00a0mg\/kg) was administered by oral gavage; blood pressure was monitored daily. The production of NADPH oxidase was measured, and cardiac hypertrophy and apoptosis were detected. The results revealed that PMQ could downregulate the expression of the NADPH oxidase gene and reduce angiotensin\u00a0II- induced cardiac hypertrophy and apoptosis in rats. Therefore, we believe that PMQ showed beneficial effects on myocardium in angiotensin\u00a0II-administered rats, and its potential to be used for treatment of cardiovascular disease deserves further attention. <\/jats:p>","DOI":"10.1139\/y09-069","type":"journal-article","created":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T18:20:19Z","timestamp":1254334819000},"page":"720-728","source":"Crossref","is-referenced-by-count":17,"title":["3,3\u2032,4\u2032,5,7-Pentamethylquercetin reduces angiotensin\u00a0II-induced cardiac hypertrophy and apoptosis in rats"],"prefix":"10.1139","volume":"87","author":[{"given":"Zhangfan","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China."},{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."},{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China."},{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."},{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinling","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China."},{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."},{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongquan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China."},{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."},{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"rg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0302.103712"},{"key":"rg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000196728.05488.c3"},{"key":"rg3\/ref3","unstructured":"Buhler, V. 2005. Polyvinylpyrrolidone excipients for pharmaceuticals: povidone, crospovidone and copovidone. Springer, New York."},{"key":"rg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000099504.30207.F5"},{"key":"rg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00233-5"},{"key":"rg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00851.2003"},{"key":"rg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.162800"},{"issue":"1","key":"rg8\/ref8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/jn\/136.1.39","volume":"136","author":"Graf B.A.","year":"2006","journal-title":"J. Nutr."},{"key":"rg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000174986.73346.ba"},{"key":"rg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/45673"},{"issue":"7","key":"rg11\/ref11","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1161\/01.CIR.96.7.2414","volume":"96","author":"Hill M.F.","year":"1997","journal-title":"Circulation"},{"key":"rg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601624"},{"issue":"4","key":"rg13\/ref13","first-page":"404","volume":"7","author":"Ikizler M.","year":"2007","journal-title":"Anadolu Kardiyol. Derg."},{"key":"rg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990701)20:10<2046::AID-ELPS2046>3.0.CO;2-C"},{"key":"rg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0333"},{"key":"rg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8719(93)90008-3"},{"key":"rg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000035087.11758.ED"},{"key":"rg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-109"},{"key":"rg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.12.0002"},{"key":"rg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI316"},{"key":"rg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.275.20.1557"},{"issue":"5","key":"rg22\/ref22","first-page":"H2313","volume":"272","author":"Li Z.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"rg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000032031.30374.32"},{"key":"rg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500214"},{"key":"rg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00203-X"},{"key":"rg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.11.002"},{"issue":"7","key":"rg27\/ref27","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1161\/01.CIR.94.7.1506","volume":"94","author":"Misao J.","year":"1996","journal-title":"Circulation"},{"key":"rg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000012569.55432.02"},{"key":"rg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520160303"},{"key":"rg30\/ref30","unstructured":"Robinson, B.V., Sullivan, F.M., Borzelleca, J.F., and Schwartz, S.L. 1990. PVP: a critical review of the kinetics and toxicology of polyvinylpyrrolidone (povidone). Lewis, Michigan."},{"key":"rg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000035392.38687.65"},{"issue":"1","key":"rg32\/ref32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01.hjh.0000198029.22472.d9","volume":"24","author":"S\u00e1nchez M.","year":"2006","journal-title":"J. Hypertens."},{"issue":"4","key":"rg33\/ref33","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/jn\/137.4.910","volume":"137","author":"S\u00e1nchez M.","year":"2007","journal-title":"J. Nutr."},{"key":"rg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.1526"},{"key":"rg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026215712983"},{"key":"rg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.04.015"},{"key":"rg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.04.002"},{"key":"rg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1080\/00498250600630636"},{"key":"rg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200404000-00023"},{"issue":"6","key":"rg40\/ref40","first-page":"757","volume":"37","author":"Zhang X.H.","year":"2008","journal-title":"ACTA Med. Univ. Sci. Technol. Huazhong."}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/Y09-069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/Y09-069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T03:50:46Z","timestamp":1578282646000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/Y09-069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1139\/Y09-069"],"URL":"https:\/\/doi.org\/10.1139\/y09-069","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}