{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:20:00Z","timestamp":1761895200811,"version":"3.38.0"},"reference-count":12,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>The hepatorenal reflex, activated by intrahepatic adenosine, is involved in the regulation of urine production in healthy rats and renal pathogenesis secondary to liver injury. Hepatic adenosine A<jats:sub>1<\/jats:sub>receptors regulate the hepatorenal reflex. The aim of the present study was to evaluate whether caffeine mediates renal natriuresis and diuresis in healthy and diseased liver through this mechanism. Rats were anesthetized and instrumented to monitor systemic, hepatic, and renal circulation and urine production. Intrahepatic (intraportal but not intravenous) caffeine (5\u00a0mg\u00b7kg<jats:sup>\u20131<\/jats:sup>) increased urine flow (~82%) in healthy rats. This effect was abolished by liver denervation. Intraportal infusion of adenosine decreased urine production, and this response was abolished by intraportal but not intravenous caffeine. Liver injury was induced by intraperitoneal injection of thioacetamide (500\u00a0mg\u00b7kg<jats:sup>\u20131<\/jats:sup>), and functional assessment was performed 24\u00a0h later. Liver injury was associated with lower (~30%) glomerular filtration rate, lower (~18%) renal arterial blood flow, and lower urine production. Intraportal but not intravenous caffeine improved basal urine production and renal ability to increase urine production in response to saline overload. The liver-dependent diuretic effect of caffeine is consistent with the hypothesis for the adenosine-mediated mechanism of hepatorenal syndrome.<\/jats:p>","DOI":"10.1139\/y10-090","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T20:37:21Z","timestamp":1289507841000},"page":"1115-1121","source":"Crossref","is-referenced-by-count":17,"title":["Caffeine-induced natriuresis and diuresis via blockade of hepatic adenosine-mediated sensory nerves and a hepatorenal reflex"],"prefix":"10.1139","volume":"88","author":[{"given":"Zhi","family":"Ming","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210-753 McDermot Avenue, Winnipeg, MB R3E\u00a00W3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Wayne","family":"Lautt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, A210-753 McDermot Avenue, Winnipeg, MB R3E\u00a00W3, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"rg1\/ref1","doi-asserted-by":"publisher","DOI":"10.2741\/2852"},{"key":"rg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1995.tb00111.x"},{"key":"rg3\/ref3","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161100-00002"},{"key":"rg4\/ref4","unstructured":"Lautt, W.W. 1981. Role and control of the hepatic artery.InHepatic circulation in health and disease.Edited byW.W. Lautt. Raven Press, New York, N.Y. pp.\u00a0203\u2013226."},{"issue":"2","key":"rg5\/ref5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0022-3565(25)12746-8","volume":"254","author":"Lautt W.W.","year":"1990","journal-title":"J. Pharmacol. Exp. 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