{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:35:46Z","timestamp":1761510946053,"version":"3.38.0"},"reference-count":42,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>The therapeutic effects of poly(adenosine diphosphate-ribose) polymerase inhibition by 3-aminobenzamide (3-AB) were investigated in testicular ischemia\u2013reperfusion (I\/R) injury, using sperm analysis and histopathological and biochemical examinations, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and reduced glutathione (GSH) levels. Male rats were divided into 3 groups: sham (n = 12), I\/R (n = 12), and I\/R with 3-AB (I\/R\u20133-AB) (n = 12). The left testicular artery was occluded for 1 h, followed by 24 h (for biochemical and histopathological examinations) and 30\u00a0days (for sperm analysis) of reperfusion. 3-AB treatment intraperitoneally 10 min prior to and 1 h after reperfusion increased the I\/R-induced decrease in sperm motility in both testes and reduced the increased abnormal sperm rates in the ipsilateral testis. However, 3-AB treatment failed to prevent the I\/R-induced decrease in sperm concentration in both testes. SOD and CAT activities did not change in any group. GSH-Px activity and GSH levels were increased by I\/R. 3-AB treatment reversed the I\/R-induced increase in GSH-Px activity, similar to the level in sham rats, but did not alter GSH levels. 3-AB treatment significantly increased the I\/R-induced decrease in histopathologic score. In conclusion, 3-AB treatment has potential biochemical and histopathological benefits beyond improving sperm quality and may have the potential to decrease damage from testicular torsion.<\/jats:p>","DOI":"10.1139\/y10-093","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T14:41:15Z","timestamp":1293028875000},"page":"1123-1129","source":"Crossref","is-referenced-by-count":3,"title":["Effects of 3-aminobenzamide on unilateral testicular ischemia\u2013reperfusion injury: What is the role of PARP inhibition?"],"prefix":"10.1139","volume":"88","author":[{"given":"Askin","family":"Hekimoglu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey."},{"name":"Department of Pharmacology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey."},{"name":"Department of Artificial Insemination and Reproduction, Bor Vocational School, Nigde University, Nigde, Turkey."},{"name":"Department of Pathology, Selcuklu Medical Faculty, Selcuk University, Konya, Turkey."},{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, F\u0131rat University, Elazig, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Kurcer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey."},{"name":"Department of Pharmacology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey."},{"name":"Department of Artificial Insemination and Reproduction, Bor Vocational School, Nigde University, Nigde, Turkey."},{"name":"Department of Pathology, Selcuklu Medical Faculty, Selcuk University, Konya, Turkey."},{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, F\u0131rat University, Elazig, 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