{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T16:01:15Z","timestamp":1648915275761},"reference-count":32,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p> (\u2013)Doxazosin, one of (\u00b1)doxazosin enantiomers, was speculated to have a pharmacological enantioselectivity between the cardiovascular system and the urinary system by comparison with (+)doxazosin. Therefore, to evaluate the potential benefits of (\u2013)doxazosin in the treatment of benign prostate hyperplasia, we compared the effects of the 3 agents, using rat mesenteric artery preparations and obstructed bladder strips. Concentration\u2013response curves for carbachol (contractile response) and isoprenaline (relaxant response) in detrusor muscle strips of the bladder outlet obstruction (BOO) rats were shifted to the left, with significant increases in the E<jats:sub>max<\/jats:sub> values, and significant decreases in the EC<jats:sub>50<\/jats:sub> values by comparison with the sham-operated rats (P\u00a0&lt; 0.05, n = 10). The enhanced responses in detrusor muscle strips of the BOO rats treated with (\u00b1)doxazosin and its enantiomers at 3\u00a0mg\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup>\u00b7day<jats:sup>\u20131<\/jats:sup> for 2\u00a0weeks returned to normal levels, and the 3 agents inhibited the enhanced responses to carbachol and isoprenaline to the same extent. On the other hand, the 3 agents uncompetitively inhibited the vasoconstrictive response curves for NA in the rat isolated mesenteric artery, and the pK<jats:sub>B<\/jats:sub> value of (\u2013)doxazosin at vascular \u03b1<jats:sub>1<\/jats:sub>-adrenoceptors was significantly smaller (P\u00a0&lt; 0.05, n = 6) than that of (+)doxazosin or (\u00b1)doxazosin. In conclusion, although (\u2013)doxazosin inhibits vascular functional \u03b1<jats:sub>1<\/jats:sub>-adrenoceptors more weakly than (+)doxazosin, both agents equally ameliorate the enhanced responses in detrusor muscle of BOO rats, suggesting that the chiral carbon atom in the molecular structure of doxazosin does not affect its beneficial effects in the bladder smooth muscle of BOO rats. <\/jats:p>","DOI":"10.1139\/y11-087","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T16:11:30Z","timestamp":1322237490000},"page":"883-890","source":"Crossref","is-referenced-by-count":1,"title":["Relaxant and contractile responses of detrusor muscle strips obtained from bladder outlet-obstructed rats treated with doxazosin enantiomers"],"prefix":"10.1139","volume":"89","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Chinese Integrative Medicine, Hebei Medical University, 361 East Zhong-shan Road, Shijiazhuang 050017, Hebei, P. R. China."},{"name":"New Drug Research and Development Centre of North China Pharmaceutical Group Corporation, 388 East He-ping Road, Shijiazhuang 050015, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Jiao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Fourth Affiliated Hospital, Hebei Medical Univerity, Shijiazhuang 050011, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"New Drug Research and Development Centre of North China Pharmaceutical Group Corporation, 388 East He-ping Road, Shijiazhuang 050015, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"New Drug Research and Development Centre of North China Pharmaceutical Group Corporation, 388 East He-ping Road, Shijiazhuang 050015, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Integrative Medicine, Hebei Medical University, 361 East Zhong-shan Road, Shijiazhuang 050017, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Integrative Medicine, Hebei Medical University, 361 East Zhong-shan Road, Shijiazhuang 050017, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei-Ming","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Chinese Integrative Medicine, Hebei Medical University, 361 East Zhong-shan Road, Shijiazhuang 050017, Hebei, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"issue":"5","key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"R1654","DOI":"10.1152\/ajpregu.1998.275.5.R1654","volume":"275","author":"Braverman A.S.","year":"1998","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1569-9056(04)90505-2","volume":"29","author":"Chapple C.R.","year":"1996","journal-title":"Eur. Urol."},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2003.09.001"},{"key":"refg4\/ref4","first-page":"S3","volume":"7","author":"Dmochowski R.R.","year":"2005","journal-title":"Rev. Urol."},{"issue":"2","key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"H606","DOI":"10.1152\/ajpheart.01016.2001","volume":"283","author":"Dora K.A.","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67776-2"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65355-4"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1990.tb14957.x"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00502-X"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02032.x"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68997-5"},{"issue":"4","key":"refg12\/ref12","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0022-5347(17)45874-5","volume":"135","author":"Levin R.M.","year":"1986","journal-title":"J. Urol."},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00443.x"},{"issue":"6","key":"refg14\/ref14","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/S0022-5347(17)53503-X","volume":"128","author":"Mattiasson A.","year":"1982","journal-title":"J. Urol."},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030656"},{"issue":"1","key":"refg16\/ref16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1476-5381.1990.tb14678.x","volume":"99","author":"Muramatsu I.","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00475-0"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0320869"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.02.017"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700933"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000097026.43866.cc"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.05.023"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702351"},{"issue":"3","key":"refg24\/ref24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0022-5347(17)35683-5","volume":"150","author":"Saito M.","year":"1993","journal-title":"J. Urol."},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63305-6"},{"issue":"4","key":"refg26\/ref26","doi-asserted-by":"crossref","first-page":"F644","DOI":"10.1152\/ajprenal.00274.2002","volume":"284","author":"Su X.L.","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"2","key":"refg27\/ref27","first-page":"118","volume":"21","author":"Tian H.L.","year":"2007","journal-title":"Chin. J. Pharmacol. Toxicol."},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181a6b14d"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FPE03002X"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703152"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.12.004"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.04.057"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/y11-087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y11-087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T01:46:12Z","timestamp":1578275172000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y11-087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1139\/y11-087"],"URL":"https:\/\/doi.org\/10.1139\/y11-087","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}