{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:39:37Z","timestamp":1759541977009},"reference-count":45,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p> The androgen nandrolone decanoate (ND) is known to cause cardiovascular abnormalities, such as attenuation of the Bezold\u2013Jarisch Reflex (BJR), cardiac hypertrophy, and elevation of mean arterial pressure (MAP). Futhermore, a relationship between androgens and the renin\u2013angiotensin system (RAS) has been reported. The purpose of this study was to evaluate the influence of RAS on the BJR, cardiac and prostatic hypertrophy, and MAP evoked by ND. For this, male Wistar rats were treated with ND (10\u00a0mg\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup> for 8\u00a0weeks; DECA), or vehicle (control animals; CON), or enalapril (10\u00a0mg\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup>, daily; CONE), or ND and enalapril (10\u00a0mg ND + 10\u00a0mg enalapril per kilogram of body mass; DECAE). After 8\u00a0weeks of treatment, the BJR was evaluated by bradycardia and hypotensive responses that were elicited by serotonin administration (2\u201332\u00a0\u00b5g\u00b7(kg body mass)<jats:sup>\u20131<\/jats:sup>). MAP was assessed; cardiac and prostate hypertrophy were determined by the ratio of the tissue mass:body mass, and by histological analysis of the heart. Animals from the DECA group showed prostatic and cardiac hypertrophy, elevation in mean arterial pressure, and an impairment of BJR. Co-treatment with enalapril inhibited these changes. The data from the present study suggest that RAS has an impact on BJR attenuation, cardiac and prostatic hypertrophy, and the elevation in MAP evoked by ND. <\/jats:p>","DOI":"10.1139\/y11-090","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T21:11:30Z","timestamp":1322255490000},"page":"891-897","source":"Crossref","is-referenced-by-count":12,"title":["Role of the renin\u2013angiotensin system in the nandrolone-decanoate-induced attenuation of the Bezold\u2013Jarisch reflex"],"prefix":"10.1139","volume":"89","author":[{"given":"Tadeu","family":"Uggere de Andrade","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University Center of Vila Velha, Esp\u00edrito Santo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Zanoteli","family":"Loiola","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center, Federal University of Esp\u00edrito Santo, Avenida Marechal Campos, 1468, Vit\u00f3ria, ES 29042-755, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira Merces Nascimento","family":"Alcure","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University Center of Vila Velha, Esp\u00edrito Santo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Raquel Santos","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center, Federal University of Esp\u00edrito Santo, Avenida Marechal Campos, 1468, Vit\u00f3ria, ES 29042-755, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmen Lopes Ferreira Silva","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University Center of Vila Velha, Esp\u00edrito Santo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareth Ribeiro","family":"Moys\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center, Federal University of Esp\u00edrito Santo, Avenida Marechal Campos, 1468, Vit\u00f3ria, ES 29042-755, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00e1ucia Rodrigues de","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center, Federal University of Esp\u00edrito Santo, Avenida Marechal Campos, 1468, Vit\u00f3ria, ES 29042-755, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University Center of Vila Velha, Esp\u00edrito Santo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazar\u00e9 Souza","family":"Bissoli","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Health Sciences Center, Federal University of Esp\u00edrito Santo, Avenida Marechal Campos, 1468, Vit\u00f3ria, ES 29042-755, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000144125.61927.1c"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.03.010"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04613.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.06.020"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.11.003"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.03.001"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)02326-7"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00305.2004"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00130.2007"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.10.3469"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.078"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000174600.51515.e7"},{"issue":"4","key":"refg13\/ref13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3727\/000000001783992551","volume":"9","author":"Dadras S.S.","year":"2001","journal-title":"Gene Expr."},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1002\/path.1021"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200111000-00012"},{"issue":"5","key":"refg16\/ref16","doi-asserted-by":"crossref","first-page":"H1997","DOI":"10.1152\/ajpheart.01054.2001","volume":"283","author":"Freshour J.R.","year":"2002","journal-title":"Am. 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