{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:17:06Z","timestamp":1792027026249,"version":"4.4.0"},"reference-count":29,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>The present study deals with the pharmacological effects of the sesquiterpene alcohol (\u2013)-\u03b1-bisabolol on various smooth-muscle preparations from rats. Under resting tonus, (\u2013)-\u03b1-bisabolol (30\u2013300\u00a0\u00b5mol\/L) relaxed duodenal strips, whereas it showed biphasic effects in other preparations, contracting endothelium-intact aortic rings and urinary bladder strips, and relaxing these tissues at higher concentrations (600\u20131000\u00a0\u00b5mol\/L). In preparations precontracted either electromechanically (by 60\u00a0mmol\/L K<jats:sup>+<\/jats:sup>) or pharmacomechanically (by phenylephrine or carbachol), (\u2013)-\u03b1-bisabolol showed only relaxing properties. The pharmacological potency of (\u2013)-\u03b1-bisabolol was variable, being higher in mesenteric vessels, whereas it exerted relaxing activity with a lesser potency on tracheal or colonic tissues. In tissues possessing spontaneous activity, (\u2013)-\u03b1-bisabolol completely decreased spontaneous contractions in duodenum, whereas it increased their amplitude in urinary bladder tissue. Administered in vivo, (\u2013)-\u03b1-bisabolol attenuated the increased responses of carbachol in tracheal rings of ovalbumin-sensitized rats challenged with ovalbumin, but was without effect in the decreased responsiveness of urinary bladder strips in mice treated with ifosfamide. In summary, (\u2013)-\u03b1-bisabolol is biologically active in smooth muscle. In some tissues, (\u2013)-\u03b1-bisabolol preferentially relaxed contractions induced electromechanically, especially in tracheal smooth muscle. The findings from tracheal rings reveal that (\u2013)-\u03b1-bisabolol may be an inhibitor of voltage-dependent Ca<jats:sup>2+<\/jats:sup>channels.<\/jats:p>","DOI":"10.1139\/y11-094","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T17:15:46Z","timestamp":1326215746000},"page":"23-35","source":"Crossref","is-referenced-by-count":24,"title":["In-vitro characterization of the pharmacological effects induced by (\u2013)-\u03b1-bisabolol in rat smooth muscle preparations"],"prefix":"10.1139","volume":"90","author":[{"given":"Rodrigo J.B.","family":"de Siqueira","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter B.S.","family":"Freire","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A.","family":"Vasconcelos-Silva","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia A.","family":"Fonseca-Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Faculdade de Farm\u00e1cia, Odontologia e Enfermagem, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.B.","family":"Lima","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresinha S.","family":"Brito","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia T.C.","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo A.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Lahlou","sequence":"additional","affiliation":[{"name":"Instituto Superior de Ci\u00eancias Biom\u00e9dicas, Universidade Estadual do Cear\u00e1, Fortaleza, CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.C.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Faculdade de Farm\u00e1cia, Odontologia e Enfermagem, Universidade Federal do Cear\u00e1, Fortaleza, CE, Brazil."},{"name":"Rua Cel Nunes de Melo 1127, Rodolfo Te\u00f3filo, Fortaleza, CE, CEP 60430-270 Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"atypb1\/ref300","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1074901"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81133-2"},{"issue":"2","key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0031-6997(24)01362-0","volume":"50","author":"Caulfield M.P.","year":"1998","journal-title":"Pharmacol. 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