{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:19:12Z","timestamp":1773659952533,"version":"3.50.1"},"reference-count":64,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Corticosteroids are used in the management of several epileptic aliments; however, their effectiveness in combating seizures remains controversial, with pro- and anti-convulsive effects ascribed. The current study aimed to address the modulatory effect of dexamethasone (DEX) utilizing 3 dose levels (5, 10, and 20\u00a0mg\/kg body mass of male Wistar rat) in the rat lithium\u2013pilocarpine (Li-PIL) epilepsy model. Li-PIL induced seizures that were associated with neuronal cell loss in the CA3 region, and increased prostaglandin (PG)E<jats:sub>2<\/jats:sub>, tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-10, nitric oxide, and neutrophil infiltration in the hippocampus. However, Li-PIL compromised the oxidant\u2013antioxidant balance of the hippocampus. Effective anticonvulsant activity was only observed with10\u00a0mg\u00a0DEX\/kg body mass, which reduced seizure production and incidence, as well as neuronal cell loss in the CA3 region. At this anticonvulsant dose, enhancements in the antioxidant system and IL-10, as well as suppression of altered inflammatory markers were observed. Conversely, doubling the dose showed a tendency to shorten seizure latency, and neither affected seizure incidence nor CA3 neuronal cell loss. These effects were associated with an increase in levels of PGE<jats:sub>2<\/jats:sub>and TNF-\u03b1. The present study found a lack of protection at 5\u00a0mg\u00a0DEX\/kg body mass, an anticonvulsant effect at 10\u00a0mg\/kg, and a loss of protection at 20\u00a0mg\/kg in the Li-PIL epilepsy model, which indicates that there is an optimal dose of DEX for preventing the induction of seizures.<\/jats:p>","DOI":"10.1139\/y11-096","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T17:15:46Z","timestamp":1326215746000},"page":"13-21","source":"Crossref","is-referenced-by-count":21,"title":["Diverse effects of variant doses of dexamethasone in lithium\u2013pilocarpine induced seizures in rats"],"prefix":"10.1139","volume":"90","author":[{"given":"Muhammad Y.","family":"Al-Shorbagy","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Str, 11562 Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahia M.","family":"El Sayeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Str, 11562 Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalaal M.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Str, 11562 Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"atypb1\/ref400","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.06.034"},{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.11.080"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000242058"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06766.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959411"},{"key":"refg5\/ref5","first-page":"879","volume":"44","author":"Bazan N.G.","year":"1986","journal-title":"Adv. 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