{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:04:27Z","timestamp":1760346267215},"reference-count":23,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>The birdseed Phalaris canariensis (Pc) is popularly used as an antihypertensive agent. The aqueous extract of Pc (AEPc) was administered in adult normotensive Wistar rats and spontaneously hypertensive rats (SHR) and in prehypertensive young SHR (SHR<jats:sub>Y<\/jats:sub>, 3\u00a0weeks old). Animals received AEPc (400\u00a0mg\u00b7kg<jats:sup>\u20131<\/jats:sup>\u00b7day<jats:sup>\u20131<\/jats:sup>, by gavage) for 30\u00a0days, then groups were divided into 2 subgroups: one was treated for another 30\u00a0days and the other received water instead of AEPc for 30\u00a0days. AEPc reduced systolic blood pressure (SBP) in both adult groups; however, treatment interruption was followed by a gradual return of the SBP to baseline levels. SHR<jats:sub>Y<\/jats:sub>became hypertensive 30\u00a0days after weaning. AEPc minimized the increase in SBP in SHR<jats:sub>Y<\/jats:sub>, but blood pressure rose to levels similar to those in the untreated group with treatment interruption. There were no changes in renal function, diuresis, or Na<jats:sup>+<\/jats:sup>excretion. Pc is rich in tryptophan, and the inhibition of the metabolism of tryptophan to kynurenine, a potential vasodilator factor, prevented the blood pressure reducing effect of AEPc. Moreover, AEPc significantly reduced sympathoexcitation. Data indicate that the metabolic derivative of tryptophan, kinurenine, may be a mediator of the volume-independent antihypertensive effect of Pc, which was at least in part mediated by suppression of the sympathetic tonus.<\/jats:p>","DOI":"10.1139\/y11-120","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T16:15:12Z","timestamp":1329236112000},"page":"201-208","source":"Crossref","is-referenced-by-count":15,"title":["Blood pressure reducing effects of<i>Phalaris canariensis<\/i>in normotensive and spontaneously hypertensive rats"],"prefix":"10.1139","volume":"90","author":[{"given":"Cl\u00e9via Santos","family":"Passos","sequence":"first","affiliation":[{"name":"Renal Division, Federal University of S\u00e3o Paulo (UNIFESP), Rua Botucatu, 740, 04023-900, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucimeire Nova","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Renal Division, Federal University of S\u00e3o Paulo (UNIFESP), Rua Botucatu, 740, 04023-900, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Roberto Braz","family":"Pontes","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy Ribeiro","family":"Campos","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olinda","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Renal Division, Federal University of S\u00e3o Paulo (UNIFESP), Rua Botucatu, 740, 04023-900, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian Aparecida","family":"Boim","sequence":"additional","affiliation":[{"name":"Renal Division, Federal University of S\u00e3o Paulo (UNIFESP), Rua Botucatu, 740, 04023-900, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1021\/jf970100x"},{"issue":"6","key":"refg2\/ref2","first-page":"299","volume":"23","author":"Adrian J.","year":"1969","journal-title":"Ann. 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