{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:35:06Z","timestamp":1762101306035},"reference-count":63,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p> The endocrine pancreas is critically important in the regulation of energy metabolism, with defective insulin secretion from pancreatic islet \u03b2-cells a major contributing factor to the development of type 2 diabetes. Small ubiquitin-like modifier (SUMO) proteins have been demonstrated to covalently modify a wide range of target proteins, mediating a broad range of cellular processes. While the effects of SUMOylation on \u03b2-cell gene transcription have been previously reviewed, recent reports indicate roles for SUMO outside of the nucleus. In this review we shall focus on the reported non-nuclear roles of SUMOylation in the regulation of \u03b2-cells, including SUMOylation as a novel signaling pathway in the acute regulation of insulin secretion. <\/jats:p>","DOI":"10.1139\/y11-134","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T10:47:10Z","timestamp":1338202030000},"page":"765-770","source":"Crossref","is-referenced-by-count":15,"title":["Novel roles of SUMO in pancreatic \u03b2-cells: thinking outside the nucleus"],"prefix":"10.1139","volume":"90","author":[{"given":"Jocelyn E.","family":"Manning Fox","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Alberta Diabetes Institute, Li Ka Shing Centre, University of Alberta, Edmonton, AB T6G\u00a02E1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Hajmrle","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Alberta Diabetes Institute, Li Ka Shing Centre, University of Alberta, Edmonton, AB T6G\u00a02E1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick E.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Alberta Diabetes Institute, Li Ka Shing Centre, University of Alberta, Edmonton, AB T6G\u00a02E1, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1023\/B:REMD.0000021435.87776.a7"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606702104"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00630-X"},{"issue":"5","key":"refg4\/ref4","first-page":"971","volume":"13","author":"Boddy M.N.","year":"1996","journal-title":"Oncogene"},{"issue":"6","key":"refg5\/ref5","first-page":"1161","volume":"46","author":"Chen A.","year":"1998","journal-title":"Biochem. 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