{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:43:27Z","timestamp":1788295407696,"version":"build-2803163510"},"reference-count":50,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>This study was conducted to evaluate the modulatory effect of aqueous extract of Curcuma longa (L.) against \u03b3-irradiation (GR), which induces biochemical disorders in male rats. The sublethal dose of GR was determined in primary hepatocytes. Also, the effect of C.\u00a0longa extract was examined for its activity against GR. In rats, C.\u00a0longa extract was administered daily (200\u00a0mg\/kg body mass) for 21\u00a0days before, and 7\u00a0days after GR exposure (6.5 Gy). The lipid profile and antioxidant status, as well as levels of transaminases, interleukin-6 (IL-6), and tumour necrosis factor\u00a0\u03b1 (TNF\u03b1) were assessed. The results showed that in hepatocytes, the aqueous extract exhibited radioprotective activity against exposure to GR. Exposure of untreated rats to GR resulted in transaminase disorders, lipid abnormalities, elevation of lipid peroxidation, trace element alterations, release of IL-6 and TNF, and decrease in glutathione and protein level of superoxide dismutase-1 (SOD-1) and peroxiredoxin-1 (PRDX-1). However, treatment of rats with this extract before and after GR exposure improved antioxidant status and minimized the radiation-induced increase in inflammatory cytokines. Changes occurred in the tissue levels of trace elements, and the protein levels of SOD-1 and PRDX-1 were also modulated by C.\u00a0longa extract. Overall, C.\u00a0longa exerted a beneficial radioprotective effect against radiation-induced oxidative stress in male rats by alleviating pathological disorders and modulating antioxidant enzymes.<\/jats:p>","DOI":"10.1139\/y2012-005","type":"journal-article","created":{"date-parts":[[2012,3,30]],"date-time":"2012-03-30T13:22:19Z","timestamp":1333113739000},"page":"415-423","source":"Crossref","is-referenced-by-count":23,"title":["Radioprotective effect of<i>Curcuma longa<\/i>extract on \u03b3-irradiation-induced oxidative stress in rats"],"prefix":"10.1139","volume":"90","author":[{"given":"Ahmed S.","family":"Nada","sequence":"first","affiliation":[{"name":"National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Nasr City, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrar M.","family":"Hawas","sequence":"additional","affiliation":[{"name":"National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Nasr City, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour El-Din","family":"Amin","sequence":"additional","affiliation":[{"name":"National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Nasr City, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy M.","family":"Elnashar","sequence":"additional","affiliation":[{"name":"Laboratory of Biopolymers & Nanobiotechnology, Polymers Department, Center of Excellence, National Research Center, Dokki, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria Y.","family":"Abd Elmageed","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Helwan University, Cairo, Egypt."},{"name":"Department of Urology and Oncology, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(93)90022-N"},{"issue":"1","key":"refg2\/ref2","first-page":"71","volume":"6","author":"Ashok P.","year":"2004","journal-title":"Asian J. 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