{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:55:53Z","timestamp":1778550953435,"version":"3.51.4"},"reference-count":38,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxidative stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normotensive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt\u2019s method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension.<\/jats:p>","DOI":"10.1139\/y2012-078","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T13:29:05Z","timestamp":1345814945000},"page":"1229-1234","source":"Crossref","is-referenced-by-count":12,"title":["Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model"],"prefix":"10.1139","volume":"90","author":[{"given":"Jaqueline","family":"Barp","sequence":"first","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmem Luiza","family":"Sart\u00f3rio","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Campos","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Francisca","family":"Llesuy","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex Sander","family":"Araujo","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane","family":"Bell\u00f3-Klein","sequence":"additional","affiliation":[{"name":"Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2003.11.008"},{"issue":"5","key":"refg3\/ref3","first-page":"270","volume":"15","author":"Amirkhizi F.","year":"2010","journal-title":"J. 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