{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:11:30Z","timestamp":1788261090819,"version":"build-2803163510"},"reference-count":47,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Diabetes remains a major public health issue. According to the American Diabetes Association, 23.5 million, or 10.7% of people in the USA aged 20\u00a0years and older, have diabetes. Type-2 diabetes is treated both by controlling the diet and with oral hypoglycemic drugs. However, for many patients, achieving a tight control of glucose is difficult with current regimens. This chapter discusses a relatively low-cost dietary supplement that could be used as an adjuvant therapy for type-2 diabetes. A review of the literature indicates that cysteine-rich whey protein improves glucose metabolism in diabetic animals and type-2 diabetic patients. Similarly, in animal studies, improvement in glucose metabolism is observed after supplementation with L-cysteine, or molecules containing a cysteine moiety. This chapter discusses the biochemical mechanisms by which L-cysteine can upregulate the insulin-dependent signaling cascades of glucose metabolism. Further studies are needed to examine whether clinical interventions using L-cysteine as an adjuvant therapy indeed help to control glycemia and vascular inflammation in the diabetic patient population.<\/jats:p>","DOI":"10.1139\/y2012-087","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T18:02:31Z","timestamp":1343066551000},"page":"1061-1064","source":"Crossref","is-referenced-by-count":28,"title":["<scp>L<\/scp>-Cysteine supplementation as an adjuvant therapy for type-2 diabetes"],"prefix":"10.1139","volume":"90","author":[{"given":"Sushil K.","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pediatrics, LSU Health Sciences Center, 1501 Kings Highway Shreveport, LA 71130, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520290405"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00598.2010"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.01.006"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2006.10.002"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.01.006"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.026"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05865.x"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807974105"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00436.x"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.05.039"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1770"},{"issue":"1","key":"refg12\/ref12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ajcn\/82.1.69","volume":"82","author":"Frid A.H.","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"refg13\/ref13","doi-asserted-by":"crossref","first-page":"E744","DOI":"10.1152\/ajpendo.00355.2002","volume":"285","author":"Haber C.A.","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"13","key":"refg14\/ref14","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1096\/fasebj.13.13.1845","volume":"13","author":"Ho E.","year":"1999","journal-title":"FASEB J."},{"issue":"12","key":"refg15\/ref15","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1093\/jn\/134.12.3245","volume":"134","author":"Hsu C.C.","year":"2004","journal-title":"J. Nutr."},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2132"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005017"},{"issue":"35","key":"refg18\/ref18","doi-asserted-by":"crossref","first-page":"21340","DOI":"10.1016\/S0021-9258(19)30085-7","volume":"264","author":"Jain S.K.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.38.12.1539"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90310-9"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2287"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.7.2139"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.03.014"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2956"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00377.2008"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.128363"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.12.2398"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2282"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100505"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-004-1305-4"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.11.012"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.270884"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510000991"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-8-47"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199807000-00016"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.006"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1006"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.003483"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.133736"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp111"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2253"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.12.018"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10857"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179333"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1761-5"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1080\/09637480701253581"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/y2012-087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y2012-087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T19:33:32Z","timestamp":1642880012000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y2012-087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1139\/y2012-087"],"URL":"https:\/\/doi.org\/10.1139\/y2012-087","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}