{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:21:03Z","timestamp":1742800863761},"reference-count":30,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p> We investigated the effects of arsenic trioxide (As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>) as a possible approach for preventing airway remodeling in a murine model of bronchial asthma induced by ovalbumin (OVA) challenge. Forty Balb\/c mice were randomly assigned to 1 of 4 groups (10 mice\/group) as follows: controls (challenged with sterile saline inhalation only); OVA-challenged, no treatment; OVA-challenged, treated with dexamethasone; and OVA-challenged, treated with As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>. All mice were sensitized by intraperitoneal injection with 10% OVA at 2\u00a0weeks prior to saline or OVA inhalation challenge. Challenges were for 8\u00a0weeks. After OVA challenge, typical asthma-like morphology changes in the bronchi and lung tissues were observed by hematoxylin\u2013eosin staining and pulmonary function indices were reduced compared with controls. Changes in pulmonary indices and lung tissues were similar in the dexamethasone and As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> groups and were in between those of the untreated and control groups. Compared with the untreated group, transforming growth factor \u03b21, vascular endothelial growth factor, and matrix metalloproteinase-9 protein levels and mRNA expression were decreased in lung tissues of the dexamethasone and As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> groups. Our results suggest that steroids and As<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> can inhibit airway remodeling in chronic asthma by mechanisms related to inhibiting the expression of the 3 aforementioned mediators. <\/jats:p>","DOI":"10.1139\/y2012-127","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T15:27:24Z","timestamp":1354634844000},"page":"1576-1584","source":"Crossref","is-referenced-by-count":5,"title":["Effects of arsenic trioxide (As<sub>2<\/sub>O<sub>3<\/sub>) on airway remodeling in a murine model of bronchial asthma"],"prefix":"10.1139","volume":"90","author":[{"given":"Zi-ping","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University, No.155 Nanjing Street, Heping District, Shenyang, Liaoning Province, 110001 P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-min","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, No.\u00a023 Post Street, Nangang District, Harbin, Heilongjiang Province, 150001 P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-lan","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, No.\u00a023 Post Street, Nangang District, Harbin, Heilongjiang Province, 150001 P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Kang","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University, No.155 Nanjing Street, Heping District, Shenyang, Liaoning Province, 110001 P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Shanxi Provincial People\u2019s Hospital, No.\u00a029 Two Towers Street, Yingze District, Taiyuan, Shanxi Province, 030012 P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","unstructured":"Barnes, P.J. 2003. Pathophysioslogy of allergic inflammation. In Middleton\u2019s allergy principles and practices. 6th ed. Mosby, St. Louis, Mo. p. 483."},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200402-014MS"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1030OC"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00130004"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.09.019"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.4.852"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.26"},{"issue":"4","key":"refg10\/ref10","first-page":"323","volume":"55","author":"Filosso P.L.","year":"2003","journal-title":"Minerva Pediatr."},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.06.004"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01071.x"},{"issue":"3","key":"refg14\/ref14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1164\/ajrccm.162.3.9908016","volume":"162","author":"Kelly E.A.","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.053819"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nm1105"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.9.941"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.139543"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.5.1543"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.06.031"},{"issue":"14","key":"refg21\/ref21","first-page":"3893","volume":"62","author":"Miller W.H.","year":"2002","journal-title":"Cancer Res."},{"issue":"3","key":"refg22\/ref22","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1165\/ajrcmb.17.3.2733","volume":"17","author":"Minshall E.M.","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3350"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1707"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900003200"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120024594"},{"key":"refg27\/ref27","first-page":"130","volume":"42","author":"Wang W.J.","year":"2007","journal-title":"Journal of Zhengzhou University \u2013 Medical Sciences"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1464"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.12.899"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1007\/BF02838615"},{"key":"refg31\/ref31","first-page":"5017","volume":"8","author":"Zhou L.F.","year":"2004","journal-title":"Chinese Journal of Clinical Rehabilitation"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-146"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/full-xml\/10.1139\/y2012-127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y2012-127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T05:18:59Z","timestamp":1578287939000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y2012-127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1139\/y2012-127"],"URL":"https:\/\/doi.org\/10.1139\/y2012-127","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}