{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T20:35:59Z","timestamp":1726173359873},"reference-count":8,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[1964,1,1]],"date-time":"1964-01-01T00:00:00Z","timestamp":-189388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1964,1,1]]},"abstract":"<jats:p> A proteolytic enzyme (Aspergillin-O) derived from Aspergillus Oryzae was studied. For this purpose arterial and venous occluding thrombi in dogs were subjected to systemic treatment with the enzyme, and the value of Aspergillin-O in thrombolytic therapy, as well as its toxic side effects and some aspects of its pharmacology are described. Lysis of occluding arterial thrombi was achieved within a few hours after the administration of enzyme preparations by single intravenous injection, and arteries remained patent during the week of post-treatment observation. The thrombolytic dose was found to vary from animal to animal, but was generally comparable in its effect to a dose of human fibrinolysin of between 250 and 300 Michigan Department of Health caseinolytic units. The variations in dose requirements and toxicity were attributed to individual protease resistance, and a dose prediction test based on this concept is described. The dose prediction test was found to make possible the safe and efficient use of the enzyme in systemic thrombolytic therapy. <\/jats:p>","DOI":"10.1139\/y64-013","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:41:11Z","timestamp":1303634471000},"page":"109-125","source":"Crossref","is-referenced-by-count":20,"title":["THE EVALUATION IN THE DOG OF A PROTEOLYTIC ENZYME DERIVED FROM ASPERGILLUS ORYZAE"],"prefix":"10.1139","volume":"42","author":[{"given":"Walter H. E.","family":"Roschlau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"p_3\/p_3_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3181\/00379727-102-25191","volume":"102","author":"HORACE M.","year":"1959","journal-title":"STEFANIXI. Proc. Soc. Exptl. Hiol. Metl."},{"key":"p_6\/p_6_1","first-page":"799","volume":"59","author":"KAKACA M.","year":"1962","journal-title":"J. Lab. Clin. Med."},{"key":"p_7\/p_7_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/0002-9343(62)90251-6","volume":"33","author":"TLETCHER N .","year":"1962","journal-title":"Atn. J. Medo"},{"key":"p_8\/p_8_1","first-page":"346","volume":"40","author":"JULI EKTZ","year":"1952","journal-title":"Biochem. Hiophys."},{"key":"p_10\/p_10_1","first-page":"1819","volume":"40","author":"PAINTER","journal-title":"J. Hiochern. Pkysiol."},{"key":"p_11\/p_11_1","first-page":"201","volume":"68","author":"AI ESIG","year":"1957","journal-title":"J. Clill. Invest."},{"key":"p_14\/p_14_1","first-page":"343","volume":"39","author":"SIIEKKY A.","year":"1959","journal-title":"Physiol. Wcv."},{"key":"p_16\/p_16_1","first-page":"202","volume":"1","author":"SHERKY P.","year":"1960","journal-title":"Therap."}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y64-013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:16:22Z","timestamp":1578240982000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y64-013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,1,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1964,1,1]]}},"alternative-id":["10.1139\/y64-013"],"URL":"https:\/\/doi.org\/10.1139\/y64-013","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1964,1,1]]}}}