{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:00:41Z","timestamp":1756994441634},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1969,2,1]],"date-time":"1969-02-01T00:00:00Z","timestamp":-28857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1969,2,1]]},"abstract":"<jats:p> Propranolol 0.016\u2002mg\/kg was given to 15 patients with pulmonary stenosis to study the effects of beta adrenergic inhibition on right ventricular (RV) dynamics at rest and during exercise. After propranolol, mean heart rate declined 8 beats\/min at rest and 21 beats\/min during exercise; mean cardiac index decreased 0.6\u2002l\/min at rest, 1.0\u2002l\/min during exercise; stroke index decreased 4.0\u2002ml at rest, was unchanged during exercise; mean peak systolic RV pressure fell 8\u2002mm at rest, 24\u2002mm during exercise; RV end-diastolic pressure increased 3\u2002mm during exercise; brachial artery systolic pressure decreased 24\u2002mm during exercise; the duration of RV systole during exercise was increased by 0.03\u2002s; mean RV pressures decreased 5\u2002mm at rest, 11\u2002mm during exercise; RV tension time index decreased 20% at rest, 26% during exercise; and mean mixed venous oxygen saturation during exercise fell from 42 to 35%. This study serves to emphasize that peak RV pressures in pulmonary stenosis are not only dependent on valvular anatomy and stroke volume, but also on the rate and pattern of ventricular ejection. <\/jats:p>","DOI":"10.1139\/y69-024","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:38:35Z","timestamp":1303591115000},"page":"137-142","source":"Crossref","is-referenced-by-count":4,"title":["Effects of propranolol on the resting and exercise hemodynamics of pulmonary stenosis"],"prefix":"10.1139","volume":"47","author":[{"given":"Gordon R.","family":"Cumming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Mir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y69-024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:17:47Z","timestamp":1578241067000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y69-024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,2,1]]}},"alternative-id":["10.1139\/y69-024"],"URL":"https:\/\/doi.org\/10.1139\/y69-024","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,2,1]]}}}