{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:30:25Z","timestamp":1770831025589,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[1969,8,1]],"date-time":"1969-08-01T00:00:00Z","timestamp":-13219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1969,8,1]]},"abstract":"<jats:p> Chronic administration of morphine sulfate to rats caused a decrease in accumulation of p-aminohippurate (PAH) by renal cortex slices. No apparent effect on PAH accumulation was observed following a single injection of morphine or when the narcotic was added directly to the incubation medium. Electron microscopic studies showed marked changes in the morphology of the kidney in morphine-treated rats; inconstant but massive macroscopic and microscopic lesions were observed in the renal cortex, medulla, and papilla of rats treated chronically with the narcotic. <\/jats:p>","DOI":"10.1139\/y69-112","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:39:07Z","timestamp":1303591147000},"page":"649-655","source":"Crossref","is-referenced-by-count":20,"title":["Evidence for the nephrotoxicity of morphine sulfate in rats"],"prefix":"10.1139","volume":"47","author":[{"given":"Claude","family":"Marchand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Cantin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y69-112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:18:00Z","timestamp":1578241080000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y69-112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1969,8,1]]}},"alternative-id":["10.1139\/y69-112"],"URL":"https:\/\/doi.org\/10.1139\/y69-112","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,8,1]]}}}