{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:02:15Z","timestamp":1768687335421,"version":"3.49.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1971,2,1]],"date-time":"1971-02-01T00:00:00Z","timestamp":34214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1971,2,1]]},"abstract":"<jats:p> Weanling rabbits were fed a vitamin A deficient diet for 6 weeks. During this period they failed to gain weight normally and exhibited significantly lower serum vitamin A levels when compared with their littermates fed a vitamin A supplemented diet. These findings indicated that vitamin A deficiency was established, and the lungs and specimens of aorta were removed for study. The pressure\u2013volume relationships of saline-filled lungs revealed that test lungs were more compliant than control lungs and this difference was associated with a decrease in elastin content in test lungs. The absence of such changes in pair-fed controls suggests that the effects are due to vitamin A deficiency per se rather than the general effects of retarded growth. A decrease was also noted in the elastance of the aorta, confirming that vitamin A deficiency has an effect on elasticity of tissues generally. When vitamin A deficient animals were given vitamin A supplemented diets the elastance of the aorta returned to control values but the compliance of the lung, although somewhat decreased, did not reach control values. The mechanism by which vitamin A deficiency affects tissue elasticity is not known. <\/jats:p>","DOI":"10.1139\/y71-018","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:40:15Z","timestamp":1303576815000},"page":"127-133","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Vitamin A Deficiency in Rabbits on the Elastic Properties of the Lung and Thoracic Aorta"],"prefix":"10.1139","volume":"49","author":[{"given":"J. S.","family":"Saksena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Naimark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y71-018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:17:33Z","timestamp":1578223053000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y71-018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1971,2,1]]}},"alternative-id":["10.1139\/y71-018"],"URL":"https:\/\/doi.org\/10.1139\/y71-018","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,2,1]]}}}