{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:58:48Z","timestamp":1760079528800},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1972,3,1]],"date-time":"1972-03-01T00:00:00Z","timestamp":68256000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1972,3,1]]},"abstract":"<jats:p> The effects of mepyramine maleate, sodium meclofenamate, methysergide bimaleate, diethylcarbamazine citrate, and disodium cromoglycate on bovine cutaneous anaphylactic reactions and responses to intradermal injections of histamine, 5-hydroxytryptamine, and bradykinin were studied. Calves sensitized by immunization with horse serum in Freund's complete adjuvant were bled to obtain skin-sensitizing serum which was used in passive cutaneous anaphylaxis (P.C.A.) tests. A latent period of 72\u2002h was allowed between intradermal injections of sera and antigen challenge. Mepyramine maleate (10\u2002mg\/kg) selectively inhibited responses to histamine and raised the threshold dose of antibody required to elicit a response. Disodium cromoglycate (DSCG, 10\u2002mg\/kg) given intravenously 30\u2002min or immediately prior to challenge had no significant effect either on the responses to drugs or on the passive cutaneous anaphylaxis reaction. Diethylcarbamazine (DECC, 20\u2002mg\/kg) administered immediately prior to challenge significantly inhibited the cutaneous anaphylactic response and when DSCG was given simultaneously with DECC, this inhibitory effect was apparently augmented. Methysergide (1\u2002mg\/kg) and sodium meclofenamate (2\u2002mg\/kg) were ineffective in suppressing P.C.A. It is concluded that histamine and a slow-reacting substance (SRS-A) are involved in the mediation of bovine cutaneous anaphylaxis and that kinins may contribute, while 5-hydroxytryptamine would appear unimportant. <\/jats:p>","DOI":"10.1139\/y72-038","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:41:43Z","timestamp":1303576903000},"page":"255-262","source":"Crossref","is-referenced-by-count":20,"title":["The Pharmacology of Passive Cutaneous Anaphylaxis in the Calf"],"prefix":"10.1139","volume":"50","author":[{"given":"P. W.","family":"Wells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Eyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y72-038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:17:29Z","timestamp":1578223049000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y72-038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,3,1]]}},"alternative-id":["10.1139\/y72-038"],"URL":"https:\/\/doi.org\/10.1139\/y72-038","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,3,1]]}}}