{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:51:43Z","timestamp":1757541103058},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1972,6,1]],"date-time":"1972-06-01T00:00:00Z","timestamp":76204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1972,6,1]]},"abstract":"<jats:p> The following drugs have been shown to induce hepatic porphyrin accumulation in 5- to 7-weekold chickens: glutethimide, methsuximide, secobarbital, methyprylon, and mephenytoin, Since these drugs are inactive when administered to mice it is clear that a species difference exists in response to these drugs. Administration of 5\u03b2-pregnan-3\u03b1, 17\u03b1-diol-11, 20-dione to 17-day-old chick embryos results in a large increase in \u03b4-aminolevulinic acid synthase (ALA-synthase) activity accompanied by a very small increase in hepatic porphyrin levels. A drug should therefore be screened for its effects on hepatic ALA-synthase activity as well as porphyrin accumulation prior to administration to porphyric patients. Although it has been reported that ALA-synthase activity cannot be induced by drugs in the livers of newborn rats and rabbits, this enzyme is readily induced by drugs in the livers of newborn chickens. <\/jats:p>","DOI":"10.1139\/y72-074","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:42:00Z","timestamp":1303591320000},"page":"485-489","source":"Crossref","is-referenced-by-count":10,"title":["Drug-Induced Porphyrin Biosynthesis. VII. Species, Sex, and Developmental Differences in the Generation of Experimental Porphyria"],"prefix":"10.1139","volume":"50","author":[{"given":"J. M.","family":"Creighton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y72-074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:17:09Z","timestamp":1578241029000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y72-074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1972,6,1]]}},"alternative-id":["10.1139\/y72-074"],"URL":"https:\/\/doi.org\/10.1139\/y72-074","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,6,1]]}}}