{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T03:03:35Z","timestamp":1648955015906},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[1973,12,1]],"date-time":"1973-12-01T00:00:00Z","timestamp":123552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1973,12,1]]},"abstract":"<jats:p> Cinanserin was used to differentiate the effects of d-amphetamine and 2,5-dimethoxy-4-methyl-amphetamine (STP) on blood pressure and spontaneous locomotor activity in rats and mice. Cinanserin itself produced a decrease of blood pressure and spontaneous locomotor activity in the animals. A dose of 2\u2002mg\/kg of cinanserin blocked the increase of blood pressure caused by STP; however, it failed to affect the pressor action of d-amphetamine even when the dose was increased to 25\u2002mg\/kg. The increase of spontaneous locomotor activity induced by d-amphetamine was counteracted by cinanserin (10\u2002mg\/kg) but cinanserin (10 and 25\u2002mg\/kg) did not modify spontaneous locomotor activity produced by STP. The results showed that the pressor actions of STP and d-amphetamine, and most likely also their effects on spontaneous locomotor activity, were involved in different mechanisms. <\/jats:p>","DOI":"10.1139\/y73-146","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:43:34Z","timestamp":1303591414000},"page":"976-980","source":"Crossref","is-referenced-by-count":6,"title":["Differentiation of Pressor and Behavioral Effects of <i>d<\/i>-Amphetamine and 2,5-Dimethoxy-4-methylamphetamine (STP) by Cinanserin"],"prefix":"10.1139","volume":"51","author":[{"given":"Jen-Tzaw","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beng T.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y73-146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:20:45Z","timestamp":1578241245000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y73-146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1973,12,1]]}},"alternative-id":["10.1139\/y73-146"],"URL":"https:\/\/doi.org\/10.1139\/y73-146","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,12,1]]}}}