{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:08:04Z","timestamp":1762160884656},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1974,6,1]],"date-time":"1974-06-01T00:00:00Z","timestamp":139276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1974,6,1]]},"abstract":"<jats:p> Urinary and fecal excretion of <jats:sup>3<\/jats:sup>H-labelled metabolites of vitamin A was followed in rats given a single oral dose of <jats:sup>3<\/jats:sup>H-11,12-retinyl acetate (RA), followed 8 days later by a dose of non-labelled RA. The level of radioactivity in urine and feces fell to a more consistently lower level by the 8th day after administration of <jats:sup>3<\/jats:sup>H-RA but no dilution effect was seen 24\u2002h after administration of non-labelled RA. Dilution of <jats:sup>3<\/jats:sup>H-metabolites became gradually evident and was statistically significant 4\u20136 days after the administration of non-labelled RA. The results are considered to be compatible with the theory that newly absorbed vitamin A does not immediately mix with endogenous vitamin A, but is temporarily metabolized (and stored) in a separate compartment. Plasma aqueous phase contained considerable radioactivity not due to vitamin A per se; it likely represented metabolites prior to excretion. It is doubtful these originated in the liver since all hepatic radioactivity was due to retinol and retinyl esters. <\/jats:p>","DOI":"10.1139\/y74-076","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:50:04Z","timestamp":1303635004000},"page":"583-589","source":"Crossref","is-referenced-by-count":19,"title":["Compartmentation of \"Endogenous\" and Newly Absorbed Vitamin A in the Rat"],"prefix":"10.1139","volume":"52","author":[{"given":"D. L.","family":"Yeung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Veen-Baigent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y74-076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:21:24Z","timestamp":1578241284000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y74-076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,6,1]]}},"alternative-id":["10.1139\/y74-076"],"URL":"https:\/\/doi.org\/10.1139\/y74-076","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,6,1]]}}}