{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T14:37:43Z","timestamp":1648910263072},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1974,6,1]],"date-time":"1974-06-01T00:00:00Z","timestamp":139276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1974,6,1]]},"abstract":"<jats:p> The effect of metabolic inhibitors on norepinephrine (NE), epinephrine (E), tyramine (T), serotonin (5-HT), potassium chloride (KCl), and barium chloride (BaCl<jats:sub>2<\/jats:sub>) induced contraction was evaluated with the superfused canine dorsal metatarsal veins. ATP content was evaluated in the absence and presence of dinitrophenol, cyanide, azide, fluoroacetate, and iodoacetate. Contractile responses to vasoactive stimuli were measured before and during continuous superfusion with these inhibitors. Each of the metabolic inhibitors decreased tone and ATP. Dinitrophenol reduced the contractile responses of tibial arteries to NE, E, 5-HT, and KCl but abolished the contractile response to T and BaCl<jats:sub>2<\/jats:sub>. Cyanide and fluoroacetic acid did not significantly alter the contractile responses of tibial arteries to KCl or E but reduced the contractile responses to T, 5-HT, NE, and BaCl<jats:sub>2<\/jats:sub>. Azide reduced the responses to KCl, 5-HT, and T but not to NE, E, or BaCl<jats:sub>2<\/jats:sub>. Fluoroacetic acid reduced the responses to tyramine and serotonin but not to NE, E, KCl, or BaCl<jats:sub>2<\/jats:sub>. These findings are consistent with the conclusions that (1) vasoactive stimuli utilized different metabolic pathways to sustain their contractile response, (2) the adrenergic neuronal uptake mechanism or release process for catecholamines is more sensitive to metabolic inhibition than the contractile process, and (3) myogenic tone is more dependent on a functional oxidative metabolic pathway than the contractile responses to vasoactive stimuli. <\/jats:p>","DOI":"10.1139\/y74-083","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:50:04Z","timestamp":1303635004000},"page":"649-660","source":"Crossref","is-referenced-by-count":1,"title":["Differential Effect of Metabolic Inhibitors on Contractile Responses of Venous Smooth Muscle to Vasoactive Stimuli"],"prefix":"10.1139","volume":"52","author":[{"given":"S.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Heitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y74-083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:21:28Z","timestamp":1578241288000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y74-083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,6,1]]}},"alternative-id":["10.1139\/y74-083"],"URL":"https:\/\/doi.org\/10.1139\/y74-083","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,6,1]]}}}