{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T22:28:20Z","timestamp":1699050500006},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[1975,4,1]],"date-time":"1975-04-01T00:00:00Z","timestamp":165542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1975,4,1]]},"abstract":"<jats:p> The variable effect of excessive vitamin A intake on alimentary cholesterolemia was investigated in cockerels of strains of White Leghorns and New Hampshires. With the New Hampshire cockerels, the feeding of 0.5% of dietary cholesterol resulted in greater cholesterolemia when the diet contained 1\u2002700\u2002I.U. of vitamin A per kilogram than when it contained 22\u2002000\u2002I.U. of vitamin A per kilogram. With the White Leghorn cockerels, on the other hand, cholesterolemia was enhanced with the higher level of dietary vitamin A. Absorption of a single oral dose of cholesterol was increased in birds of both breeds when vitamin A had been given previously by injection. In the White Leghorn cockerels the percentage of newly absorbed cholesterol in the hepatic pool was reduced by vitamin A administration, whereas in the New Hampshire cockerels the percentage was increased. It was concluded that excess vitamin A may have divergent effects on alimentary cholesterolemia in chickens of different genetic backgrounds as a result of opposite effects on the liver\u2013blood ratio of a large load of cholesterol. <\/jats:p>","DOI":"10.1139\/y75-037","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:44:01Z","timestamp":1303577041000},"page":"256-263","source":"Crossref","is-referenced-by-count":1,"title":["Divergent Effects of Excess Dietary Vitamin A on Alimentary Cholesterolemia in Cockerels of Different Genetic Backgrounds"],"prefix":"10.1139","volume":"53","author":[{"given":"Bill","family":"Woodward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E.","family":"March","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y75-037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:21:06Z","timestamp":1578223266000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y75-037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,4,1]]}},"alternative-id":["10.1139\/y75-037"],"URL":"https:\/\/doi.org\/10.1139\/y75-037","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,4,1]]}}}