{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:27:31Z","timestamp":1759541251485},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1975,6,1]]},"abstract":"<jats:p> Adult male rats were pair-fed liquid diets, providing 37% of calories as ethanol or sucrose, for 1 month. Alcohol dehydrogenase (ADH) activity in the cytosol fractions of liver homogenates from the two groups did not differ with respect to total activity per 100\u2002g body weight, K<jats:sub>m<\/jats:sub> for ethanol, or K<jats:sub>i<\/jats:sub> for pyrazole. Other rats, fed in the same way, were fasted for 18\u201324\u2002h, then given an intraperitoneal injection of pyrazole followed 1\u2002h later by an injection of ethanol, 3\u2002g\/kg. Blood alcohol curves showed an unexplained slower rise to maximum level in the chronic alcohol group. Both groups showed a period of several hours in which the blood alcohol stayed at the respective maximum concentrations, which were higher in the control group. After 7\u20138\u2002h the alcohol concentration began to fall in both groups, significantly more rapidly in the chronic alcohol-fed animals. A kinetic analysis shows that the results are adequately explained by the known effects of pyrazole on the ADH\u2013mitochondrial system. The results are interpreted as evidence against the function of any microsomal ethanol oxidizing system in vivo. <\/jats:p>","DOI":"10.1139\/y75-060","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:50:20Z","timestamp":1303635020000},"page":"416-422","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Pyrazole on Ethanol Metabolism in Ethanol-Tolerant Rats"],"prefix":"10.1139","volume":"53","author":[{"given":"H.","family":"Kalant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Endrenyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y75-060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:21:26Z","timestamp":1578241286000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y75-060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,6,1]]}},"alternative-id":["10.1139\/y75-060"],"URL":"https:\/\/doi.org\/10.1139\/y75-060","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,6,1]]}}}