{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:47:31Z","timestamp":1769222851875,"version":"3.49.0"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1975,6,1]]},"abstract":"<jats:p> Preganglionic stimulation of the cat's superior cervical ganglion in the presence of hemicholinium-3 (HC-3) produced the expected depletion of acetylcholine (ACh) stores, but failed to cause a corresponding reduction in the choline content. These results suggest that either HC-3 possesses an intracellular site of action or that in lower doses it selectively inhibits a specialized choline transport system in cholinergic nerves. At a dose of 2\u2002mg\/kg, HC-3 probably blocked ACh synthesis completely in ganglia stimulated at 20\u2002Hz. Under these conditions, there was a rapid depletion of ACh to about 50% of control levels during the first 5\u2002min of stimulation and thereafter the rate of decline in ACh levels proceeded at a much slower pace. Since the 2\u2002mg\/kg dose of HC-3 did not raise plasma choline concentrations, it may be assumed that non-specialized choline transport systems in other tissues were not significantly inhibited by this dose of HC-3. However, when the dose of HC-3 was increased to 4\u2002mg\/kg, plasma choline levels increased by 58%. <\/jats:p>","DOI":"10.1139\/y75-064","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T04:50:20Z","timestamp":1303620620000},"page":"451-457","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Hemicholinium-3 on Choline and Acetylcholine Levels in a Sympathetic Ganglion"],"prefix":"10.1139","volume":"53","author":[{"given":"J. C.","family":"Khatter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. D.","family":"Friesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y75-064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:21:28Z","timestamp":1578223288000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y75-064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,6,1]]}},"alternative-id":["10.1139\/y75-064"],"URL":"https:\/\/doi.org\/10.1139\/y75-064","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,6,1]]}}}