{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T21:24:29Z","timestamp":1649107469249},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[1975,10,1]],"date-time":"1975-10-01T00:00:00Z","timestamp":181353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1975,10,1]]},"abstract":"<jats:p> An evaluation of the stimulus\u2013secretion coupling hypothesis was undertaken by the intracarotid administration of synthetic thyroid releasing hormone (TRH) while recording the transmembrane potential (V<jats:sub>m<\/jats:sub>) and membrane resistance (R<jats:sub>m<\/jats:sub>) of cells in the adenohypophysis of propylthiouracil pretreated male rats. Of those 75 cells which responded to TRH administration with a change in membrane parameters, the most predominant effect was a depolarization with a decrease in R<jats:sub>m<\/jats:sub> observed in 21 cells, or no change in V<jats:sub>m<\/jats:sub> but an increase in R<jats:sub>m<\/jats:sub> observed in 23 cells. These results are discussed in terms of the thyrotrophs and other cells comprising the adenohypophysis. <\/jats:p>","DOI":"10.1139\/y75-107","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:50:22Z","timestamp":1303635022000},"page":"777-786","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Synthetic TRH on Transmembrane Potential and Membrane Resistance of Adenohypophysial Cells"],"prefix":"10.1139","volume":"53","author":[{"given":"D. H.","family":"York","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kraicer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y75-107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:20:14Z","timestamp":1578241214000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y75-107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,10,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1975,10,1]]}},"alternative-id":["10.1139\/y75-107"],"URL":"https:\/\/doi.org\/10.1139\/y75-107","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,10,1]]}}}