{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:29:05Z","timestamp":1715534945968},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[1976,2,1]],"date-time":"1976-02-01T00:00:00Z","timestamp":191980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1976,2,1]]},"abstract":"<jats:p> Chronic experiments were carried out on three groups of rats to evaluate tissue and electrolyte effects of a mineralocorticoid blocker canrenoate potassium (SC-14266) during DOCA-induced hypokalemic metabolic alkalosis. Group I animals received DOCA alone, group II received DOCA plus canrenoate, while group III received canrenoate alone. The daily dose ratio (per kilogram of body weight) was 180\u2002mg canrenoate \u2013 0.45\u2002mg DOCA. All animals ate a synthetic diet and drank 0.15\u2002N NaHCO<jats:sub>3<\/jats:sub> Group II animals demonstrated a lesser degree of metabolic alkalosis and a higher muscle potassium content when compared with group I rats. The most conspicuous histological abnormality was myocardial necrosis, the degree and extent of which was impressively reduced by the blocking agent. <\/jats:p>","DOI":"10.1139\/y76-009","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:44:43Z","timestamp":1303591483000},"page":"59-65","source":"Crossref","is-referenced-by-count":5,"title":["Effects on tissue and electrolytes of a mineralocorticoid blocker during DOCA-induced potassium depletion"],"prefix":"10.1139","volume":"54","author":[{"given":"David Z.","family":"Levine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiriti","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y76-009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:19:32Z","timestamp":1578241172000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y76-009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,2,1]]}},"alternative-id":["10.1139\/y76-009"],"URL":"https:\/\/doi.org\/10.1139\/y76-009","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,2,1]]}}}