{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T20:14:23Z","timestamp":1648757663003},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1976,8,1]],"date-time":"1976-08-01T00:00:00Z","timestamp":207705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1976,8,1]]},"abstract":"<jats:p> A decrease in amplitude and conduction speed in the compound action potential is observed with time in gar olfactory and rabbit vagus nerve when it is stimulated between 4 and 15\u2002Hz at 26 \u00b0C in vitro. The amplitude decays exponentially for 1\u20133 min before reaching a steady state. Recovery also occurs exponentially. The fatigue exponential time constant is 15\u2002s for gar olfactory nerve and 50\u2002s for rabbit vagus nerve. The steady state values are 14% and 36% of the original amplitude, respectively, and conduction speeds are reduced by 25% in both nerves. The effect results from competition between ion flow during the action potential and active transport. The accumulation of K<jats:sup>+<\/jats:sup> ions and depletion of Na<jats:sup>+<\/jats:sup> ions in the restricted extracellular space contributes to the amplitude fatigue while the depletion of Na<jats:sup>+<\/jats:sup> ions alone causes the decrease in conduction speed. Ouabain increases the fatigue rate in both preparations, but more so for gar. The fatigue and recovery measurements may provide a useful method to investigate active pumping, including both the total pumping rate and the electrogenic component. <\/jats:p>","DOI":"10.1139\/y76-068","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:50:34Z","timestamp":1303635034000},"page":"485-493","source":"Crossref","is-referenced-by-count":2,"title":["Action potential fatigue in nonmyelinated nerve fibers: garfish olfactory and rabbit vagus nerve"],"prefix":"10.1139","volume":"54","author":[{"given":"Douglas A.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Sherebrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y76-068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:20:32Z","timestamp":1578241232000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y76-068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1976,8,1]]}},"alternative-id":["10.1139\/y76-068"],"URL":"https:\/\/doi.org\/10.1139\/y76-068","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,8,1]]}}}