{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:23:02Z","timestamp":1773422582179,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[1977,2,1]],"date-time":"1977-02-01T00:00:00Z","timestamp":223603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1977,2,1]]},"abstract":"<jats:p> Both the kidney and colon secrete bicarbonate and transport water and electrolytes. The respective contributions of these two organs to acid\u2013base and electrolyte balance in normal man has thus been studied in eight healthy male volunteers who underwent simultaneous renal clearance studies, and colonic perfusion with a 0.9% saline or 7.2% mannitol solution, during metabolic alkalosis and acidosis, extracellular volume expansion, and control conditions. There was no influence of these acid\u2013base conditions on electrolyte transport in the colon. In the urine, preferential loss of chloride over sodium averaged 81, 143 (P\u2002&lt;\u20020.001), and 141 (P\u2002&lt;\u20020.05)\u2002\u03bcequiv.\/min, during control, metabolic acidosis, and extracellular volume expansion conditions, respectively. During alkalosis more sodium than chloride was lost (146\u2002\u03bcequiv.\/min) (P\u2002&lt;\u20020.001). Colonic pH averaged 7.41 during saline and 6.75 (P\u2002&lt;\u20020.005) during mannitol perfusion. Titratable acid was not produced in the colon during saline perfusion, and averaged 18\u2002\u03bcequiv.\/min during mannitol perfusion. Urinary titratable acid increased from 19 to 25\u2002\u03bcequiv.\/min (P\u2002&lt;\u20020.01) during volume expansion. With saline perfusion, bicarbonate secretion rate in the colon rose from 249\u2002\u03bcequiv.\/min during control conditions to 289\u2002\u03bcequiv.\/min during metabolic alkalosis (P\u2002&lt;\u20020.05). More bicarbonate was excreted in the urine during alkalosis when mannitol was introduced in the colon (243\u2002\u03bcequiv.\/min) than when saline was perfused (152\u2002\u03bcequiv.\/min) (P\u2002&lt;\u20020.05). This study indicates that the response of the human colon is trivial compared with that of the kidney during acute changes in acid\u2013base balance. <\/jats:p>","DOI":"10.1139\/y77-003","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T16:44:14Z","timestamp":1303577054000},"page":"13-20","source":"Crossref","is-referenced-by-count":2,"title":["Effects of saline infusion and acute metabolic acidosis and alkalosis on water and electrolyte transport in the human colon"],"prefix":"10.1139","volume":"55","author":[{"given":"R.","family":"Crepeau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Romeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Devroede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. E.","family":"Plante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y77-003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:19:28Z","timestamp":1578223168000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y77-003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,2,1]]}},"alternative-id":["10.1139\/y77-003"],"URL":"https:\/\/doi.org\/10.1139\/y77-003","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,2,1]]}}}