{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T21:06:00Z","timestamp":1697835960545},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[1978,12,1]],"date-time":"1978-12-01T00:00:00Z","timestamp":281318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1978,12,1]]},"abstract":"<jats:p> Passive anaphylaxis induced in the rat hind paw and peritoneal cavity with rat serum containing immunoglobulin E antibody was inhibited by N-(2-oxo-3,5,7-cycloheptatrien-1-yl)-aminooxoacetic acid ethyl ester (AY-25,674). In contrast with disodium cromoglycate (DSCG), AY-25,674 was orally active. Otherwise, the activity profile of AY-25,674 was similar to that of DSCG. Peak activity occurred a short time after administration, large doses produced tachyphylaxis, and anaphylactic histamine release from mast cells was inhibited. AY-25,674 did not inhibit increased vascular permeability produced by nonreaginic antibody, compound 48\/80, serotonin, or histamine. It is concluded that AY-25,674 produces its antiallergic effects by inhibiting mediator release from mast cells by a mechanism similar to that of DSCG. <\/jats:p>","DOI":"10.1139\/y78-160","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:51:09Z","timestamp":1303635069000},"page":"1005-1010","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of passive anaphylaxis induced in the rat hind paw and peritoneal cavity by <i>N<\/i>-(2-oxo-3,5,7-cycloheptatrien-l-yl)-aminooxoacetic acid ethyl ester (AY-25,674)"],"prefix":"10.1139","volume":"56","author":[{"given":"R. R.","family":"Martel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Klicius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y78-160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:20:06Z","timestamp":1578241206000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y78-160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,12,1]]}},"alternative-id":["10.1139\/y78-160"],"URL":"https:\/\/doi.org\/10.1139\/y78-160","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,12,1]]}}}