{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:59:35Z","timestamp":1648763975693},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[1980,9,1]],"date-time":"1980-09-01T00:00:00Z","timestamp":336614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1980,9,1]]},"abstract":"<jats:p> A sensitive and reproducible method for the quantitation of ristocetin\u2013Willebrand factor activity in canine plasma is described. This assay measures the initial velocity of aggregation of suspensions of canine washed platelets in the presence of ristocetin and ristocetin\u2013Willebrand factor. The washed platelets are stable for 4\u2002h and when prepared from the same donor vary little in their day-to-day response to ristocetin.The calculated mean plasma ristocetin\u2013Willebrand factor activity in 37 normal dogs using this method is 98\u2002\u00b1\u200226% (mean \u00b1 SD). Ristocetin\u2013Willebrand activity is 106\u2002\u00b1\u200225% in dogs with severe hemophilia A and 45\u2002\u00b1\u200213% in dogs with moderate forms of von Willebrand's disease. <\/jats:p>","DOI":"10.1139\/y80-170","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:51:58Z","timestamp":1303635118000},"page":"1128-1134","source":"Crossref","is-referenced-by-count":3,"title":["Ristocetin\u2013Willebrand factor activity in dog plasma"],"prefix":"10.1139","volume":"58","author":[{"given":"I. B.","family":"Johnstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y80-170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:19:08Z","timestamp":1578241148000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y80-170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1980,9,1]]}},"alternative-id":["10.1139\/y80-170"],"URL":"https:\/\/doi.org\/10.1139\/y80-170","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9,1]]}}}