{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:25:55Z","timestamp":1760189155942},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:p> Six alloxan-diabetic dogs with fasting plasma glucose levels above 200\u2002mg\/100\u2002mL were treated with rectal administration of insulin suppositories twice a day for 6\u20139 days. The effectiveness was compared with that of subcutaneous insulin injections. In three diabetic dogs with fasting plasma glucose levels below 300\u2002mg\/100\u2002mL, both insulin suppository at a dose of 20\u2002U (2.3\u2002U\/kg) and subcutaneous insulin at a dose of 0.2\u2002U\/kg showed a similar effect in reducing fasting glucose levels and daily urinary glucose amounts. In dogs with higher fasting glucose levels, 0.5\u2002U of subcutaneous insulin\/kg is less effective in reducing fasting glucose than 50\u2002U (5.2\u2002U\/kg) suppositories, in spite of the same effects on daily urinary glucose output. Postprandial glucose responses were significantly lessened with rectal administration of insulin suppositories. The integrated area of increase in peripheral insulin concentration after subcutaneous injection of 0.2 or 0.5\u2002U insulin\/kg was significantly greater than that after rectal administration of an insulin suppository (2.3 or 5.2\u2002U\/kg, respectively). These results indicate that diabetes could be controlled by the daily rectal administration of an insulin suppository instead of the conventional subcutaneous injection. <\/jats:p>","DOI":"10.1139\/y81-001","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T09:47:48Z","timestamp":1290678468000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["The effect of rectal administration of insulin on the short-term treatment of alloxan-diabetic dogs"],"prefix":"10.1139","volume":"59","author":[{"given":"Yoshimitsu","family":"Yamasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Shichiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Kawamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyohiko","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Hakui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y81-001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:19:05Z","timestamp":1578223145000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y81-001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1,1]]}},"alternative-id":["10.1139\/y81-001"],"URL":"https:\/\/doi.org\/10.1139\/y81-001","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1,1]]}}}