{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T06:32:02Z","timestamp":1721197922441},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[1981,3,1]],"date-time":"1981-03-01T00:00:00Z","timestamp":352252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1981,3,1]]},"abstract":"<jats:p> Changes in the distribution of the tapeworm Hymenolepis diminuta in the rat small intestine were studied for up to 3\u2002h following intraperitoneal, intramuscular, subcutaneous, and oral administration of 5-HT. Changes in 5-HT levels in the arterial circulation, intestinal lumen, and in worm tissue were also monitored.In all cases following 5-HT administration there was an anteriad migration by H. diminuta. The extent of the migration was dose dependent, the higher the dose the more marked the migration response.Normal 5-HT levels in the parasitized gut are higher than those in uninfected animals. The pattern of increasing levels of 5-HT in worm tissue directly followed the increases in the intestinal lumen, suggesting that worm 5-HT was of host origin. Blood 5-HT levels similarly followed luminal increases.It is suggested that the pharmacological action of 5-HT on H. diminuta resulting in worm migration is implemented through the regulation of helminth neuromuscular activity and carbohydrate metabolism, as has been demonstrated in other parasitic worms. <\/jats:p>","DOI":"10.1139\/y81-044","type":"journal-article","created":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T10:49:41Z","timestamp":1508064581000},"page":"281-286","source":"Crossref","is-referenced-by-count":21,"title":["Migration of <i>Hymenolepis diminuta<\/i> (Cestoda) and changes in 5-HT (serotonin) levels in the rat host following parenteral and oral 5-HT administration"],"prefix":"10.1139","volume":"59","author":[{"given":"D. F.","family":"Mettrick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y81-044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T11:23:28Z","timestamp":1578223408000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y81-044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3,1]]}},"alternative-id":["10.1139\/y81-044"],"URL":"https:\/\/doi.org\/10.1139\/y81-044","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3,1]]}}}