{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:15:51Z","timestamp":1759342551800},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"4","license":[{"start":{"date-parts":[[1981,4,1]],"date-time":"1981-04-01T00:00:00Z","timestamp":354931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1981,4,1]]},"abstract":"<jats:p> Almitrine, a long-lasting peripheral chemoreceptor stimulant, was given to nine dogs via intracarotid injection. Carotid chemoreceptor activity was recorded from single or few-fiber afferent nerve preparations. Doses of 10\u201320\u2002\u03bcg\/kg were generally sufficient to produce a brisk stimulatory response of less than 30\u2002min duration. In four dogs decreasing arterial [Formula: see text] was found to allow a greater than additive response to almitrine. Infusions of NaHCO<jats:sub>3<\/jats:sub> appeared to depress the response to almitrine whereas changing arterial [Formula: see text] had little effect on the carotid chemoreceptor response to almitrine. Neither dopamine infusion nor dopamine receptor blockade altered the responsiveness of the carotid chemoreceptors to almitrine. <\/jats:p>","DOI":"10.1139\/y81-063","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T20:48:13Z","timestamp":1303591693000},"page":"396-401","source":"Crossref","is-referenced-by-count":24,"title":["The response of few-fiber carotid chemoreceptor preparations to almitrine in the dog"],"prefix":"10.1139","volume":"59","author":[{"given":"Gerald E.","family":"Bisgard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y81-063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:23:36Z","timestamp":1578241416000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y81-063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,4,1]]}},"alternative-id":["10.1139\/y81-063"],"URL":"https:\/\/doi.org\/10.1139\/y81-063","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4,1]]}}}