{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:21:06Z","timestamp":1697757666523},"reference-count":0,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[1982,7,1]],"date-time":"1982-07-01T00:00:00Z","timestamp":394329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[1982,7,1]]},"abstract":"<jats:p> Systemic vascular effects of dopamine, dobutamine, and prenalterol were studied in 45 anesthetized open-chest dogs. Blood flow [Formula: see text] and right atrial pressure (Pra) were independently controlled by a right heart bypass. Transient changes in central blood volume after an acute reduction in Pra at a constant [Formula: see text] showed that blood was draining from two vascular compartments with different time constants, one fast and the other slow. Dopamine (2.5\u201310\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup>) was the most active drug with dose-related increases in heart rate 6\u201319%, arterial pressure (Pa) 3\u201336%, and venous compliance 2\u201325%. Small doses of dopamine (2.5 and 5\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup>) reduced arterial resistance of the slow time-constant compartment increasing [Formula: see text] distribution to that compartment 21\u201342%, whereas larger doses increased both arterial resistance and venous compliance in that compartment. Arterial resistance in the fast time-constant compartment increased with all doses of dopamine. Dobutamine (2.5\u201310\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup>) modestly increased heart rate 2\u201311% and Pa 9\u201312%) without altering [Formula: see text] distribution demonstrating a relatively flat dose response. Dobutamine 2.5\u20135\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup> increased venous compliance 5\u201310% while 10\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup> had no effect or decreased compliance of both compartments. Prenalterol 3\u2002\u03bcg\u2219kg<jats:sup>\u22121<\/jats:sup>\u2219min<jats:sup>\u22121<\/jats:sup> increased Pa 9% primarily by increasing arterial resistance in the fast time-constant compartment without altering heart rate or blood flow distribution. Doses of prenalterol 10\u2013100 times greater caused dose-dependent reductions in Pa and vascular compliance. In this animal model of the circulation with a fixed cardiac output, dopamine had the greatest effect on the peripheral vasculature and chronotropy. <\/jats:p>","DOI":"10.1139\/y82-136","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T08:52:22Z","timestamp":1303635142000},"page":"968-976","source":"Crossref","is-referenced-by-count":3,"title":["Effects of inotropic agents on arterial resistance and venous compliance in anesthetized dogs"],"prefix":"10.1139","volume":"60","author":[{"given":"R. I.","family":"Ogilvie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/pdf\/10.1139\/y82-136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T16:23:28Z","timestamp":1578241408000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nrcresearchpress.com\/doi\/10.1139\/y82-136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1982,7,1]]}},"alternative-id":["10.1139\/y82-136"],"URL":"https:\/\/doi.org\/10.1139\/y82-136","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7,1]]}}}